{"id":"W4385249479","doi":"10.1101/2023.07.23.550214","title":"Prostate Cancer Reshapes the Secreted and Extracellular Vesicle Urinary Proteomes","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; Princess Margaret Cancer Centre; University of Toronto; Health Sciences Centre; University Health Network","funders":"Common Fund; National Institute of Neurological Disorders and Stroke; National Human Genome Research Institute; Prostate Cancer Foundation; National Institute on Drug Abuse; Hospital for Sick Children; National Heart, Lung, and Blood Institute; National Institute of Mental Health; NIH Office of the Director; Canadian Institutes of Health Research; Prostate Cancer Canada; National Cancer Institute; National Institutes of Health","keywords":"Prostate cancer; Extracellular vesicle; Extracellular vesicles; Proteome; Extracellular; Vesicle; Cancer; Prostate; Urinary system; Chemistry; Urology; Microvesicles; Medicine; Internal medicine; Cell biology; Biology; Biochemistry; Membrane; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003920085,0.0002780694,0.0003023746,0.0006471654,0.0003230922,0.0009058072,0.0001495151,0.0002653805,0.0008316289],"category_scores_gemma":[0.000431206,0.0002177291,0.0003929888,0.0006551944,0.000317935,0.0003873967,0.0008031585,0.000688805,0.0004711867],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002738475,"about_ca_system_score_gemma":0.0005260376,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001385419,"about_ca_topic_score_gemma":0.001798684,"domain_scores_codex":[0.9997196,0.00005172743,0.00001526801,0.00005826886,0.00009801671,0.00005725814],"domain_scores_gemma":[0.999831,0.00002842742,0.00003522875,0.00003486647,0.00004190317,0.00002849919],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001916328,0.00003022925,0.00719363,0.0001743637,0.00005710288,0.0001822468,0.0001798372,0.0004084893,0.9641485,0.000842676,0.000670707,0.02592056],"study_design_scores_gemma":[0.00002980535,0.0005641062,0.1755018,0.00006540537,0.0001498481,0.002577444,0.0005113453,0.004239347,0.7779579,0.001708733,0.03663271,0.00006164702],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9695463,0.007847709,0.01525862,0.0005158955,0.00009258703,0.00008099146,0.002444976,0.0003012902,0.00391162],"genre_scores_gemma":[0.9829229,0.002899723,0.008327967,0.0001877262,0.00002785665,0.00004390137,0.001732387,0.0001196376,0.003737825],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001385419,"threshold_uncertainty_score":0.002782106,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01350556522546383,"score_gpt":0.2355996386163303,"score_spread":0.2220940733908664,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}