{"id":"W4385255337","doi":"10.3390/cells12141920","title":"Intercorrelation of Molecular Biomarkers and Clinical Phenotype Measures in Fragile X Syndrome","year":2023,"lang":"en","type":"article","venue":"Cells","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Université de Montréal; Women and Children’s Health Research Institute; University of Alberta","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; Azrieli Foundation","keywords":"Fragile X syndrome; FMR1; Autism; Phenotype; Clinical psychology; Clinical trial; Psychology; Mood; Bioinformatics; Medicine; Neuroscience; Internal medicine; Biology; Fragile x; Developmental psychology; Psychiatry; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003204313,0.0003647159,0.0003606478,0.0009651718,0.0002142294,0.0004384412,0.0001782254,0.0003673337,0.001014682],"category_scores_gemma":[0.008005281,0.0001167411,0.0002208536,0.0004813085,0.0003331974,0.0002683075,0.0005606149,0.000444223,0.0002196424],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001968719,"about_ca_system_score_gemma":0.0001673616,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006824879,"about_ca_topic_score_gemma":0.0005794863,"domain_scores_codex":[0.9981309,0.0008905298,0.0001654682,0.0003301834,0.0003617482,0.0001212004],"domain_scores_gemma":[0.9933667,0.003301691,0.001970907,0.0005123236,0.0005833569,0.0002650225],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003996754,0.00003677173,0.9912815,0.0000133985,0.0000774546,0.00008975386,0.0001094738,0.0001212798,0.003224799,0.00006254735,0.00005611646,0.004527272],"study_design_scores_gemma":[0.000004799442,0.0002373199,0.9985146,0.000002931152,0.00001729432,0.0002045061,0.00004408247,0.0001951111,0.0005572762,0.00006545327,0.0001530335,0.000003633552],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975852,0.000413247,0.0008506082,0.00004207131,0.0000157782,0.00002040872,0.0002467634,0.00001221343,0.0008136388],"genre_scores_gemma":[0.9990799,0.00005677534,0.0003761668,0.00001672787,0.00000802221,0.00001845146,0.0002195094,0.000004111929,0.0002203791],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003204313,"threshold_uncertainty_score":0.01694626,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01402672294002201,"score_gpt":0.2608626585264468,"score_spread":0.2468359355864248,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}