{"id":"W4385257759","doi":"10.1073/pnas.2300191120","title":"Social memory in female mice is rapidly modulated by 17β-estradiol through ERK and Akt modulation of synapse formation","year":2023,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Neuroendocrine regulation and behavior","field":"Psychology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada; Medical Research Centre; King's College London; Medical Research Council; Institute of Psychiatry, Psychology and Neuroscience, King’s College London; Royal Society; Government of Canada; Canada Foundation for Innovation; Menzies Centre for Australian Studies, King's College London, University of London; National Alliance for Research on Schizophrenia and Depression; Brain and Behavior Research Foundation","keywords":"Synaptogenesis; Synapse; MAPK/ERK pathway; Neuroscience; Glutamatergic; PI3K/AKT/mTOR pathway; Excitatory postsynaptic potential; Hippocampus; Excitatory synapse; Synaptic plasticity; Biology; Cell biology; Psychology; Signal transduction; Glutamate receptor; Inhibitory postsynaptic potential","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002219816,0.0008513794,0.0005330109,0.0009237177,0.0002754655,0.0005423116,0.000412815,0.0004982677,0.002806254],"category_scores_gemma":[0.00017327,0.0004059089,0.0005983271,0.0002355137,0.0005434008,0.000432669,0.0004396247,0.001582628,0.0009758371],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003996748,"about_ca_system_score_gemma":0.000286737,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006176967,"about_ca_topic_score_gemma":0.001264111,"domain_scores_codex":[0.9996769,0.00002572107,0.00002814468,0.00009100025,0.00006722934,0.0001109968],"domain_scores_gemma":[0.9996257,0.00001507359,0.0001572228,0.00003250469,0.00002892831,0.000140609],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007571024,0.0001438936,0.0006848914,0.00003922542,0.00001352487,0.0001422963,0.00003710896,0.00003392655,0.9956023,0.000114665,0.0001039177,0.002327139],"study_design_scores_gemma":[0.0002076032,0.001905257,0.0543313,0.00004673445,0.00007999314,0.0007009783,0.0001840185,0.0009199497,0.9372586,0.0003884135,0.003941163,0.00003604061],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928145,0.001629233,0.001380689,0.0003515213,0.00008927658,0.00003567477,0.001297399,0.000237166,0.002164724],"genre_scores_gemma":[0.9758916,0.002096976,0.002099884,0.0002714594,0.00005510932,0.0002411968,0.001594402,0.0001596969,0.01758967],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002806254,"threshold_uncertainty_score":0.009387851,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07908643701160098,"score_gpt":0.3716837905258666,"score_spread":0.2925973535142656,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}