{"id":"W4385260085","doi":"10.3390/biology12071042","title":"Exploring Rosiglitazone’s Potential to Treat Alzheimer’s Disease through the Modulation of Brain-Derived Neurotrophic Factor","year":2023,"lang":"en","type":"review","venue":"Biology","topic":"Nerve injury and regeneration","field":"Neuroscience","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Government of Ontario; University of Guelph","keywords":"Rosiglitazone; Neurotrophic factors; Biology; Neuroscience; Disease; Brain-derived neurotrophic factor; Hyperinsulinemia; Bioinformatics; Neurodegeneration; Cognitive decline; Peroxisome proliferator-activated receptor; Type 2 diabetes; Diabetes mellitus; Insulin resistance; Endocrinology; Internal medicine; Medicine; Receptor; Dementia","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000296429,0.0006077277,0.0009186649,0.001862115,0.0002511741,0.0007783666,0.00066705,0.0007117216,0.003446176],"category_scores_gemma":[0.0003651675,0.0001951173,0.0005430807,0.001555546,0.0001890828,0.0007178998,0.000454757,0.001606929,0.001750663],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000398565,"about_ca_system_score_gemma":0.0006377432,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008803927,"about_ca_topic_score_gemma":0.00182473,"domain_scores_codex":[0.9999119,0.00001243508,0.00001431094,0.00001674793,0.00003456829,0.00001004484],"domain_scores_gemma":[0.99991,0.00003769482,0.00001373163,0.000003026079,0.00002544308,0.00001016545],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001211944,0.00009597582,0.0001153759,0.01849279,0.0001189592,0.0002292319,0.00005370945,0.000346128,0.00257902,0.003504283,0.0274079,0.9469355],"study_design_scores_gemma":[0.00004166457,0.00012248,0.0007452633,0.003220224,0.0001470778,0.0007326051,0.00004034446,0.0001004621,0.0005964751,0.001529254,0.992709,0.00001510576],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002475099,0.9975007,0.0001194771,0.0002370174,0.0002568206,0.000007690695,0.00003228967,0.00001070217,0.00158781],"genre_scores_gemma":[0.0007435812,0.9979364,0.000146085,0.0001828963,0.0001121157,0.00001041995,0.00004509416,0.000001657156,0.000821845],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003446176,"threshold_uncertainty_score":0.01152855,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.5171895675137972,"score_gpt":0.4099972518135762,"score_spread":0.107192315700221,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}