{"id":"W4385260388","doi":"10.7554/elife.87894","title":"Identifying metabolic features of colorectal cancer liability using Mendelian randomization","year":2023,"lang":"en","type":"article","venue":"eLife","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Advancing Translational Sciences; NIHR Imperial Biomedical Research Centre; Instituto de Salud Carlos III; Cancer Council Victoria; Ontario Ministry of Research and Innovation; National Health and Medical Research Council; Medical Research Council; Chonnam National University Hwasun Hospital; Biobanco Vasco; Junta de Castilla y León; Wereld Kanker Onderzoek Fonds; Xunta de Galicia; Mutuelle Générale de l'Education Nationale; School of Public Health, Imperial College London; Elizabeth Blackwell Institute for Health Research, University of Bristol; Deutsche Krebshilfe; Associazione Italiana per la Ricerca sul Cancro; Vetenskapsrådet; Stockholms Läns Landsting; Bundesministerium für Bildung und Forschung; Ministerio de Economía y Competitividad; Imperial College London; Generalitat de Catalunya; National Cancer Institute; Fundación Científica Asociación Española Contra el Cáncer; Karolinska Institutet; University of Cambridge; ZonMw; Institut Gustave-Roussy; Herzfelder'sche Familienstiftung; Grantová Agentura České Republiky; Canadian Cancer Society Research Institute; Marshfield Clinic Research Foundation; Institut National de la Santé et de la Recherche Médicale; World Cancer Research Fund; Knut och Alice Wallenbergs Stiftelse; Damon Runyon Cancer Research Foundation; University of Bristol; Chonnam National University; Centres de Recerca de Catalunya; Umeå Universitet; Ministerstvo Zdravotnictví Ceské Republiky; European Commission; Cancerfonden; Canadian Institutes of Health Research; Diabetes UK; Xarxa de Bancs de Tumors de Catalunya; World Health Organization; Memorial Sloan-Kettering Cancer Center; Wellcome Trust; Cancer Research UK; UK Research and Innovation; Génome Québec; University of South Florida; Swedish Cancer Foundation; National Heart, Lung, and Blood Institute; Florida Department of Health; National Institutes of Health; Mike and Josie Harper Cancer Research Institute; World Cancer Research Fund International; Johns Hopkins University; Univerzita Karlova v Praze; McGill University; Pelotonia; Moffitt Cancer Center; Ligue Contre le Cancer; Deutsches Krebsforschungszentrum; Agència de Gestió d'Ajuts Universitaris i de Recerca; National Institute for Health and Care Research; Division of Cancer Prevention, National Cancer Institute; Emory University; U.S. Department of Health and Human Services","keywords":"Mendelian randomization; Colorectal cancer; Biology; Genetics; Computational biology; Bioinformatics; Cancer; Medicine; Gene; Genotype; Genetic variants","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03277423,0.00122087,0.001381516,0.00241772,0.000540591,0.0009628669,0.001270798,0.001209636,0.004000291],"category_scores_gemma":[0.06646086,0.0005678221,0.002695979,0.001559467,0.00146583,0.0008724004,0.00100175,0.0009413639,0.0002619657],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006349537,"about_ca_system_score_gemma":0.001040686,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003165156,"about_ca_topic_score_gemma":0.001782382,"domain_scores_codex":[0.9555631,0.03618484,0.0009677691,0.004769505,0.001905055,0.0006096514],"domain_scores_gemma":[0.9496126,0.03845385,0.005017348,0.005994165,0.0006179113,0.0003041563],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01519112,0.000726481,0.7401632,0.0008194495,0.01522923,0.004910086,0.001382131,0.03131189,0.01356248,0.03532503,0.003527827,0.1378512],"study_design_scores_gemma":[0.003965832,0.005444408,0.4353095,0.0002506075,0.008281011,0.008005327,0.0004071918,0.4540168,0.00667608,0.07073382,0.006625681,0.0002837786],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6909424,0.0006600047,0.3023047,0.0007317325,0.0001161709,0.001150881,0.001290384,0.0007625672,0.002041249],"genre_scores_gemma":[0.9230214,0.000153654,0.07488521,0.0001225527,0.00004186492,0.0007663351,0.0004405573,0.00006392801,0.000504494],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03277423,"threshold_uncertainty_score":0.1733288,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0274004568465698,"score_gpt":0.3322968699328554,"score_spread":0.3048964130862856,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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