{"id":"W4385260747","doi":"10.7554/elife.87894.1.sa0","title":"Reviewer #2 (Public Review): Identifying metabolic features of colorectal cancer liability using Mendelian randomization","year":2023,"lang":"en","type":"peer-review","venue":"","topic":"Nutritional Studies and Diet","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Advancing Translational Sciences; NIHR Imperial Biomedical Research Centre; Instituto de Salud Carlos III; Cancer Council Victoria; Ontario Ministry of Research and Innovation; National Health and Medical Research Council; Medical Research Council; National Institutes of Health; Chonnam National University Hwasun Hospital; Biobanco Vasco; Junta de Castilla y León; Xarxa de Bancs de Tumors de Catalunya; Xunta de Galicia; Mutuelle Générale de l'Education Nationale; School of Public Health, Imperial College London; Elizabeth Blackwell Institute for Health Research, University of Bristol; Deutsche Krebshilfe; Associazione Italiana per la Ricerca sul Cancro; Vetenskapsrådet; Stockholms Läns Landsting; Imperial College London; Generalitat de Catalunya; Wereld Kanker Onderzoek Fonds; National Cancer Institute; Fundación Científica Asociación Española Contra el Cáncer; University of Cambridge; ZonMw; Institut Gustave-Roussy; Herzfelder'sche Familienstiftung; Grantová Agentura České Republiky; Canadian Cancer Society Research Institute; Institut National de la Santé et de la Recherche Médicale; Cancerfonden; Canadian Institutes of Health Research; Diabetes UK; Division of Cancer Prevention, National Cancer Institute; Agència de Gestió d'Ajuts Universitaris i de Recerca; National Institute for Health and Care Research; Wellcome Trust; Cancer Research UK; World Cancer Research Fund; Knut och Alice Wallenbergs Stiftelse; Damon Runyon Cancer Research Foundation; University of Bristol; Chonnam National University; Umeå Universitet; Centres de Recerca de Catalunya; UK Research and Innovation; Bundesministerium für Bildung und Forschung; University of South Florida; Swedish Cancer Foundation; Ligue Contre le Cancer; Deutsches Krebsforschungszentrum; Univerzita Karlova v Praze; Pelotonia; Moffitt Cancer Center; World Cancer Research Fund International; Johns Hopkins University; Ministerstvo Zdravotnictví Ceské Republiky; European Commission; Emory University; Florida Department of Health; U.S. Department of Health and Human Services","keywords":"Mendelian randomization; Colorectal cancer; Internal medicine; Medicine; Polyunsaturated fatty acid; Oncology; Cancer; Endocrinology; Fatty acid; Biology; Bioinformatics; Genetics; Genotype; Gene; Genetic variants; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.1029636,0.002175912,0.005399223,0.005297554,0.003607816,0.008214529,0.007501381,0.022238,0.05282774],"category_scores_gemma":[0.4677131,0.002259575,0.005338785,0.004372721,0.004351556,0.004776913,0.003879406,0.008601191,0.01901899],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.008197604,"about_ca_system_score_gemma":0.01692823,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006731063,"about_ca_topic_score_gemma":0.007518291,"domain_scores_codex":[0.9160182,0.03713015,0.01764129,0.006715455,0.02060665,0.001888309],"domain_scores_gemma":[0.4811055,0.1194562,0.04241259,0.02511868,0.3235825,0.00832449],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001203735,0.000006906202,0.0002364107,0.00584965,0.000123306,0.00007343054,0.00007872314,0.0000333058,0.00006814006,0.0002418084,0.9857744,0.007393508],"study_design_scores_gemma":[0.00112405,0.0000774826,0.003393394,0.02567435,0.0007315075,0.0006065961,0.0003305718,0.0005986211,0.0004220089,0.003532842,0.9633326,0.0001759638],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"editorial","genre_gemma":"commentary","genre_scores_codex":[0.0004880863,0.01845223,0.003375796,0.4275559,0.5334497,0.003769298,0.006991777,0.001144384,0.004772814],"genre_scores_gemma":[0.01259516,0.01842808,0.00758163,0.6107075,0.3010992,0.01882315,0.002916932,0.001509534,0.02633877],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.1029636,"threshold_uncertainty_score":0.54453,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09108108450154302,"score_gpt":0.3953146350055653,"score_spread":0.3042335505040223,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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