{"id":"W4385264542","doi":"10.1158/1078-0432.ccr-23-0092","title":"Phase 1 Study of JNJ-64619178, a Protein Arginine Methyltransferase 5 Inhibitor, in Advanced Solid Tumors","year":2023,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Pharmacodynamics; Pharmacokinetics; Dosing; Toxicity; Internal medicine; Refractory (planetary science); Oncology; Pharmacology; Gastroenterology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003037096,0.0001643623,0.0004140043,0.0002948222,0.00007258435,0.00001434529,0.0003169209,0.0002286727,0.0000611224],"category_scores_gemma":[0.0008501022,0.0001615124,0.00012355,0.001353703,0.0002545275,0.00000836544,0.00019919,0.0006060762,0.00001930653],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007251139,"about_ca_system_score_gemma":0.0006203917,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003920564,"about_ca_topic_score_gemma":0.001536202,"domain_scores_codex":[0.9964968,0.0007325069,0.0009103553,0.0007202125,0.0006062968,0.0005338315],"domain_scores_gemma":[0.9986429,0.0001412492,0.0001033446,0.0005901838,0.0003515095,0.0001708631],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004314002,0.002889912,0.005917452,0.00009327532,0.0001116646,0.00003839114,0.0003140056,0.002590208,0.9221622,0.00001068397,0.001452757,0.06010542],"study_design_scores_gemma":[0.031466,0.01958776,0.02273664,0.000394486,0.00003300219,0.00000225867,0.001560677,0.00138768,0.9139119,0.000263374,0.008099556,0.0005567002],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968251,0.0005973367,0.00002581985,0.0004357386,0.0001937326,0.001768241,0.00003834308,0.0000239091,0.0000917787],"genre_scores_gemma":[0.9974884,0.0004671471,0.00004067391,0.00001889945,0.0004288794,0.0007605633,0.00006950418,0.00004352483,0.0006824231],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05954872,"threshold_uncertainty_score":0.6586283,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1257635174782911,"score_gpt":0.530262130136968,"score_spread":0.4044986126586769,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}