{"id":"W4385264542","doi":"10.1158/1078-0432.ccr-23-0092","title":"Phase 1 Study of JNJ-64619178, a Protein Arginine Methyltransferase 5 Inhibitor, in Advanced Solid Tumors","year":2023,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Pharmacodynamics; Pharmacokinetics; Dosing; Toxicity; Internal medicine; Refractory (planetary science); Oncology; Pharmacology; Gastroenterology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001094069,0.001225113,0.001635538,0.0002837627,0.0003702496,0.0005841856,0.0007337707,0.0006948559,0.002026933],"category_scores_gemma":[0.0003853033,0.0004228542,0.0006225316,0.0002935077,0.0005767104,0.0005068767,0.0002506182,0.001989103,0.0006252185],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005561517,"about_ca_system_score_gemma":0.001120759,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006237077,"about_ca_topic_score_gemma":0.001893865,"domain_scores_codex":[0.9996982,0.0001290767,0.00001695115,0.00005431326,0.0000500782,0.0000514867],"domain_scores_gemma":[0.9996666,0.0000402202,0.00009683325,0.00003171697,0.00003250652,0.0001320806],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1843124,0.08038989,0.01610568,0.001769641,0.001159228,0.0008103288,0.0005022653,0.00783883,0.5158913,0.000422137,0.005225259,0.1855731],"study_design_scores_gemma":[0.1955557,0.7135792,0.02518445,0.00006618878,0.0005432365,0.001641417,0.00008600547,0.003139549,0.05328381,0.0001906718,0.006682144,0.00004757353],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952353,0.001723224,0.0007341753,0.000166747,0.00005210515,0.0008773174,0.0003917708,0.00007188509,0.0007475886],"genre_scores_gemma":[0.990207,0.002089901,0.002785867,0.0003241915,0.0001120809,0.000904967,0.001778835,0.00003202894,0.001765057],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002026933,"threshold_uncertainty_score":0.006780803,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1257635174782911,"score_gpt":0.530262130136968,"score_spread":0.4044986126586769,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}