{"id":"W4385264709","doi":"10.1002/phar.2858","title":"Practical considerations for individualizing drug dosing in critically ill adults receiving renal replacement therapy","year":2023,"lang":"en","type":"review","venue":"Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy","topic":"Antibiotics Pharmacokinetics and Efficacy","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"","keywords":"Dosing; Medicine; Intensive care medicine; Renal replacement therapy; Therapeutic drug monitoring; Intensive care unit; Critically ill; Antimicrobial; Hemodialysis; Sepsis; Intensive care; Drug; Pharmacology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001449554,0.0005701279,0.001267825,0.001127661,0.000205249,0.001310018,0.0009172824,0.001437339,0.003027757],"category_scores_gemma":[0.003198952,0.0002142065,0.0007494211,0.0009759872,0.000415639,0.001491684,0.0005656575,0.002689718,0.001384912],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005106367,"about_ca_system_score_gemma":0.001474346,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009158681,"about_ca_topic_score_gemma":0.001666124,"domain_scores_codex":[0.9991981,0.0002880525,0.0001616329,0.00006688265,0.0002528606,0.00003247189],"domain_scores_gemma":[0.9985246,0.0009232723,0.0001746475,0.00003119342,0.0003041167,0.00004222804],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007233168,0.00007188072,0.0001912825,0.01741914,0.00009339692,0.0002269787,0.0001019678,0.0004223297,0.0007852695,0.004000444,0.02987719,0.9467378],"study_design_scores_gemma":[0.0000365853,0.0001326427,0.0008904638,0.01230769,0.0001757115,0.001387805,0.0001154824,0.0002506686,0.0003414459,0.003899263,0.9804342,0.00002799334],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000151792,0.9952698,0.0005866555,0.002250069,0.0003044355,0.00001381045,0.00002277789,0.00001622124,0.00138446],"genre_scores_gemma":[0.001744607,0.9948884,0.001464588,0.001039995,0.0003457997,0.00002502431,0.00002938212,0.000003658113,0.0004585699],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003027757,"threshold_uncertainty_score":0.01012892,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1395475827362588,"score_gpt":0.4699791493035135,"score_spread":0.3304315665672548,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}