{"id":"W4385266528","doi":"10.1038/s41420-023-01576-x","title":"5-Iodotubercidin sensitizes cells to RIPK1-dependent necroptosis by interfering with NFκB signaling","year":2023,"lang":"en","type":"article","venue":"Cell Death Discovery","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Novartis Pharma; Ministero dello Sviluppo Economico; Deutsche Forschungsgemeinschaft; Deutschen Konsortium für Translationale Krebsforschung; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Ontario Ministry of Economic Development and Innovation; Genome Canada; Pfizer","keywords":"Necroptosis; RIPK1; Programmed cell death; Cell biology; Kinase; FADD; Signal transduction; Chemistry; Apoptosis; Phosphorylation; p38 mitogen-activated protein kinases; MAPK/ERK pathway; Protein kinase A; Cancer research; Biology; Caspase; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001647305,0.0002550611,0.0001960259,0.00008897723,0.0001346234,0.0001429274,0.0001605379,0.0001365669,0.00001979422],"category_scores_gemma":[0.000007868772,0.0002177835,0.00009964599,0.0001812195,0.00002381497,0.0000162153,0.0002022729,0.00008950332,0.00009350933],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003114169,"about_ca_system_score_gemma":0.00003944896,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005320232,"about_ca_topic_score_gemma":0.0000170859,"domain_scores_codex":[0.9985614,0.00004054819,0.0002149295,0.0005583835,0.0002141491,0.000410626],"domain_scores_gemma":[0.9993655,0.00001673051,0.00006447475,0.0003610894,0.00004798232,0.0001442369],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001168324,0.00003714475,0.000249099,0.00003802493,0.00003389328,0.00001936681,0.00008713044,0.006112961,0.9900912,0.00002308586,0.002569964,0.0006212647],"study_design_scores_gemma":[0.0003988753,0.0003039232,0.0002296224,0.00004800365,0.00003399852,0.00000745312,0.0002435837,0.0003157492,0.9928236,0.000026823,0.005224933,0.0003434551],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.976804,0.0002076032,0.02134101,0.00007376809,0.0002926156,0.0002748074,0.00004945188,0.00005810135,0.0008987046],"genre_scores_gemma":[0.9860098,0.0002391763,0.0006856737,0.0002235653,0.0001771784,0.00002848729,0.0002873194,0.00006259738,0.01228622],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02065533,"threshold_uncertainty_score":0.8880955,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007267237305400099,"score_gpt":0.2099754751498296,"score_spread":0.2027082378444295,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}