{"id":"W4385271083","doi":"10.1038/s41586-023-06365-1","title":"Evolutionarily divergent mTOR remodels translatome for tissue regeneration","year":2023,"lang":"en","type":"article","venue":"Nature","topic":"Silk-based biomaterials and applications","field":"Materials Science","cited_by":69,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of General Medical Sciences; National Institutes of Health; Canadian Institutes of Health Research; New York Stem Cell Foundation","keywords":"Axolotl; Biology; Regeneration (biology); PI3K/AKT/mTOR pathway; Cell biology; Translation (biology); mTORC1; Ambystoma mexicanum; Signal transduction; Genetics; Messenger RNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002365124,0.00009541219,0.0001058993,0.000054936,0.0002341897,0.00005299952,0.0001659954,0.0004580024,0.0002094254],"category_scores_gemma":[0.00002882299,0.00008177354,0.00004515978,0.0002452334,0.00002597711,0.0000989181,0.0000200342,0.0001073593,0.0003356063],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003417681,"about_ca_system_score_gemma":0.00004426204,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009162767,"about_ca_topic_score_gemma":0.000008485727,"domain_scores_codex":[0.9991479,0.00002086625,0.000157119,0.0002779581,0.0001929432,0.000203223],"domain_scores_gemma":[0.9995571,0.00003207498,0.00004991277,0.0002096737,0.00009828211,0.00005295011],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002084629,0.00001337982,0.00001120498,0.00001846049,0.000002433318,5.807861e-7,0.00006280565,0.0002058023,0.9644617,0.007223898,0.02750601,0.0004728246],"study_design_scores_gemma":[0.0002739133,0.00003178994,0.00109899,0.000009934205,0.00001366648,0.000001786406,0.00001320229,0.001681196,0.9127106,0.003755923,0.08027402,0.0001349534],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9859148,0.0004205061,0.005576092,0.004847684,0.001369741,0.0006165544,0.0008068823,0.0003488122,0.00009896155],"genre_scores_gemma":[0.9937968,0.00001694784,0.003834099,0.0002869953,0.0005349384,0.0002065964,0.0003317157,0.00001617255,0.0009757327],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05276801,"threshold_uncertainty_score":0.4313651,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02043475620147727,"score_gpt":0.2941642002158971,"score_spread":0.2737294440144198,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}