{"id":"W4385273672","doi":"10.3390/metabo13080883","title":"An Integrated Multi-OMICS Approach Highlights Elevated Non-Esterified Fatty Acids Impact BeWo Trophoblast Metabolism and Lipid Processing","year":2023,"lang":"en","type":"article","venue":"Metabolites","topic":"Birth, Development, and Health","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children’s Health Research Institute; Victoria Hospital; London Health Sciences Centre; The Metabolomics Innovation Centre; Lawson Health Research Institute; University of Alberta; Western University","funders":"National Institutes of Health; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Genome Canada","keywords":"Lipid metabolism; Gestational diabetes; Trophoblast; Metabolomics; Offspring; Endocrinology; Biology; Sphingolipid; Internal medicine; Omics; Lipidomics; Placenta; NEFA; Biochemistry; Fetus; Pregnancy; Medicine; Bioinformatics; Gestation; Insulin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001405054,0.0009696878,0.001317925,0.00256718,0.0006942277,0.002894541,0.0004160586,0.0005496822,0.001857931],"category_scores_gemma":[0.001059748,0.0003231397,0.001515167,0.002755238,0.0003084504,0.0009011436,0.001341371,0.0009762718,0.0004920721],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005903232,"about_ca_system_score_gemma":0.001244089,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003037737,"about_ca_topic_score_gemma":0.005930442,"domain_scores_codex":[0.9992515,0.0001909322,0.0000609379,0.0002416527,0.0001654716,0.0000894545],"domain_scores_gemma":[0.9995396,0.0001486953,0.00007686894,0.0000693836,0.00012782,0.00003763237],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001346437,0.0002458974,0.09911493,0.004360499,0.003048299,0.0008888814,0.0008957941,0.006564545,0.7545888,0.003789231,0.003930929,0.1212258],"study_design_scores_gemma":[0.0001297681,0.001101934,0.614721,0.001514172,0.005035224,0.001815896,0.003442924,0.04605284,0.1665311,0.02906102,0.1302159,0.0003783262],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6963302,0.0435272,0.1606081,0.003479448,0.0005447862,0.0005983032,0.07794481,0.001601275,0.01536584],"genre_scores_gemma":[0.7604058,0.02440258,0.1607701,0.002625542,0.0002505861,0.000807988,0.04466628,0.0004155378,0.005655541],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003037737,"threshold_uncertainty_score":0.007430732,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0323678242571552,"score_gpt":0.3117243579029895,"score_spread":0.2793565336458343,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}