{"id":"W4385273672","doi":"10.3390/metabo13080883","title":"An Integrated Multi-OMICS Approach Highlights Elevated Non-Esterified Fatty Acids Impact BeWo Trophoblast Metabolism and Lipid Processing","year":2023,"lang":"en","type":"article","venue":"Metabolites","topic":"Birth, Development, and Health","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children’s Health Research Institute; Victoria Hospital; London Health Sciences Centre; The Metabolomics Innovation Centre; Lawson Health Research Institute; University of Alberta; Western University","funders":"National Institutes of Health; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Genome Canada","keywords":"Lipid metabolism; Gestational diabetes; Trophoblast; Metabolomics; Offspring; Endocrinology; Biology; Sphingolipid; Internal medicine; Omics; Lipidomics; Placenta; NEFA; Biochemistry; Fetus; Pregnancy; Medicine; Bioinformatics; Gestation; Insulin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006735502,0.0005331733,0.00110225,0.0005969694,0.0003304358,0.000188648,0.0002104317,0.0002992198,0.00003206079],"category_scores_gemma":[0.0001025926,0.0003775647,0.0001324366,0.001468856,0.0001659571,0.0004078747,0.00007016367,0.0005007635,0.00005350047],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007912279,"about_ca_system_score_gemma":0.0005861296,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001764029,"about_ca_topic_score_gemma":0.00001295249,"domain_scores_codex":[0.9971426,0.0001453724,0.0006668516,0.0007713764,0.0003890852,0.0008847537],"domain_scores_gemma":[0.9982831,0.00003597458,0.0002194007,0.0004812001,0.0003268242,0.0006535171],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001196251,0.001192806,0.08215327,0.001281301,0.0005580898,0.00006214638,0.01097748,0.00002941659,0.8776572,0.002758626,0.0003666086,0.0217668],"study_design_scores_gemma":[0.003851394,0.0001724856,0.9408349,0.000100775,0.0002728829,0.00005969077,0.0007670174,0.01645201,0.03268672,0.0001788142,0.004127435,0.0004959083],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925255,0.001229233,0.003857628,0.0003338506,0.0002880583,0.0008668598,0.00009330603,0.0005687143,0.0002368294],"genre_scores_gemma":[0.9473911,0.01158535,0.0385126,0.0004640563,0.0004484828,0.00009142456,0.001224949,0.00011253,0.000169495],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8586816,"threshold_uncertainty_score":0.9998676,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0323678242571552,"score_gpt":0.3117243579029895,"score_spread":0.2793565336458343,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}