{"id":"W4385284415","doi":"10.33393/dti.2009.1337","title":"A Model for NAD(P)H:Quinoneoxidoreductase 1 (NQO1) Targeted Individualized Cancer Chemotherapy","year":2009,"lang":"en","type":"article","venue":"Drug Target Insights","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Research Institute in Oncology and Hematology; CancerCare Manitoba","funders":"CancerCare Manitoba Foundation; Welch Foundation","keywords":"Medicine; Chemotherapy; Cancer imaging; Cancer chemotherapy; Oncology; NAD+ kinase; Cancer; Internal medicine; Medical physics; Bioinformatics; Cancer research; Biology; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002916013,0.0004426018,0.0005035236,0.0001840133,0.0005246404,0.00005194039,0.0004551176,0.0003183772,0.0009621379],"category_scores_gemma":[0.00002788883,0.0003903439,0.0002573479,0.0002815438,0.0001606644,0.0002473708,0.00004052778,0.0005011124,0.00004061553],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001137743,"about_ca_system_score_gemma":0.0002103738,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002288187,"about_ca_topic_score_gemma":0.00002464557,"domain_scores_codex":[0.9978075,0.0001816301,0.0004487222,0.0006071427,0.0002355814,0.0007193919],"domain_scores_gemma":[0.9988369,0.0001131113,0.0002234414,0.0002773571,0.0001998621,0.0003492684],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.004261055,0.004189475,0.002427448,0.0001646264,0.001290389,0.0001049806,0.01920116,0.006356073,0.4458682,0.01656841,0.4705331,0.02903505],"study_design_scores_gemma":[0.008864115,0.0001927486,0.001266579,0.00003502026,0.0002068946,0.00001043559,0.0001514789,0.1982723,0.2202243,0.02512953,0.5446088,0.001037806],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9801489,0.00417804,0.002809405,0.005207472,0.001790831,0.001468936,0.0007697131,0.0003001905,0.003326551],"genre_scores_gemma":[0.9744982,0.00055903,0.006387419,0.01355512,0.0005819,0.0002055618,0.0003047749,0.00005092825,0.003857123],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2256439,"threshold_uncertainty_score":0.9999511,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1214002722564105,"score_gpt":0.4299540723818994,"score_spread":0.3085538001254889,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}