{"id":"W4385289823","doi":"10.1016/j.ijrobp.2023.07.019","title":"Concurrent Lapatinib With Brain Radiation Therapy in Patients With HER2+ Breast Cancer With Brain Metastases: NRG Oncology–KROG/RTOG 1119 Phase 2 Randomized Trial","year":2023,"lang":"en","type":"article","venue":"International Journal of Radiation Oncology*Biology*Physics","topic":"Brain Metastases and Treatment","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"Jewish General Hospital","funders":"Korean Foundation for Cancer Research; NRG Oncology; National Cancer Institute; Novocure; National Institutes of Health; Varian Medical Systems","keywords":"Lapatinib; Medicine; Clinical endpoint; Radiosurgery; Internal medicine; Concomitant; Oncology; Breast cancer; Radiation therapy; Randomized controlled trial; Adverse effect; Metastatic breast cancer; Cancer; Trastuzumab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001228547,0.001863494,0.002589495,0.0003274051,0.0004258064,0.00132009,0.001006605,0.001196798,0.006437819],"category_scores_gemma":[0.001382687,0.0008920523,0.002121517,0.0004569368,0.001290757,0.00122215,0.000616146,0.003733805,0.001017129],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001413967,"about_ca_system_score_gemma":0.0013855,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002119365,"about_ca_topic_score_gemma":0.007277835,"domain_scores_codex":[0.999469,0.0002574002,0.00003103985,0.0001195498,0.00003497201,0.00008793262],"domain_scores_gemma":[0.9992349,0.0001588331,0.0001910379,0.00006261441,0.0000285957,0.0003240526],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9748512,0.003918395,0.001156326,0.0004575746,0.001392234,0.0000337714,0.0000517426,0.0006871973,0.00220004,0.0001172506,0.001031134,0.01410322],"study_design_scores_gemma":[0.9455568,0.04947215,0.002346372,0.00003434568,0.0008467577,0.00004553384,0.0000260602,0.0004357359,0.0002592499,0.0001816793,0.0007800139,0.00001539768],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877571,0.00490025,0.0004836895,0.001057353,0.0004578347,0.001710222,0.001124795,0.0001019326,0.002406959],"genre_scores_gemma":[0.9874595,0.003103954,0.001160922,0.001091234,0.0004155752,0.001924497,0.001832784,0.00003653171,0.002975039],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006437819,"threshold_uncertainty_score":0.02153659,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02188940762181953,"score_gpt":0.3658415212596814,"score_spread":0.3439521136378619,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}