{"id":"W4385294463","doi":"10.1080/19420862.2023.2239405","title":"Bivalent non-human gal-α1-3-gal glycan epitopes in the Fc region of a monoclonal antibody model can be recognized by anti-Gal-α1-3-Gal IgE antibodies","year":2023,"lang":"en","type":"article","venue":"mAbs","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; Health Canada","funders":"Government of Canada","keywords":"Bivalent (engine); Monoclonal antibody; Epitope; Antibody; Glycan; Immunoglobulin E; Chemistry; Molecular biology; Biology; Immunology; Glycoprotein","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000134389,0.0003450734,0.0001224291,0.0001111634,0.00006878957,0.0001667397,0.0002699134,0.000279245,0.0004756355],"category_scores_gemma":[0.0001126357,0.0001151455,0.0002794008,0.0001390491,0.00009826418,0.0001317437,0.0001871439,0.0004663024,0.0001915761],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002051647,"about_ca_system_score_gemma":0.00008433241,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005640346,"about_ca_topic_score_gemma":0.0008104626,"domain_scores_codex":[0.9998724,0.0000246797,0.000007820394,0.0000280502,0.00003743518,0.00002949596],"domain_scores_gemma":[0.999956,0.000006123001,0.00001213935,0.000008358852,0.000007235398,0.00001011945],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003070744,0.00001492022,0.00008063035,0.00001179253,0.000004437441,0.00002991922,0.000006148737,0.00008794923,0.9992774,0.00003967113,0.00001361233,0.0004027383],"study_design_scores_gemma":[0.00001255866,0.0003766457,0.001563092,0.000004789258,0.00002854179,0.0002159812,0.00001096866,0.00108302,0.9940752,0.00003157234,0.002593508,0.000004131391],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919681,0.0004799692,0.006531395,0.00004924178,0.0000164805,0.00003253795,0.0001112823,0.00003338532,0.0007776465],"genre_scores_gemma":[0.9922757,0.0004413769,0.005273689,0.0001041285,0.000005098838,0.00002282749,0.0004078305,0.00001371042,0.001455675],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005640346,"threshold_uncertainty_score":0.001591206,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06072787208077493,"score_gpt":0.3738455780838568,"score_spread":0.3131177060030819,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}