{"id":"W4385298686","doi":"10.1126/science.ade6967","title":"In vivo hematopoietic stem cell modification by mRNA delivery","year":2023,"lang":"en","type":"article","venue":"Science","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":304,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"Ionis Pharmaceuticals; National Heart, Lung, and Blood Institute; University of Pennsylvania; National Institutes of Health; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Children's Hospital of Philadelphia","keywords":"Haematopoiesis; Stem cell; In vivo; Biology; Hematopoietic stem cell; CD117; Transplantation; Cell biology; Cancer research; Immunology; CD34; Medicine; Genetics; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002465136,0.00006636425,0.00005354924,0.00008169161,0.0000651112,0.00003020598,0.0003290004,0.00004434165,0.00001625942],"category_scores_gemma":[0.000007769071,0.00006420622,0.00002315399,0.0004431942,0.0001296136,0.0000123961,0.00009716515,0.00003766809,0.0001696726],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000150391,"about_ca_system_score_gemma":0.00007934076,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001718311,"about_ca_topic_score_gemma":0.000006422861,"domain_scores_codex":[0.9991832,0.00001344714,0.0001104303,0.0003152779,0.0001519508,0.0002257439],"domain_scores_gemma":[0.9996209,0.000004647117,0.00003083805,0.0002447436,0.00004923277,0.00004962462],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000004825321,0.00001433575,0.0005247847,0.000004716764,6.089149e-7,0.000001673391,0.00008956796,0.00007462817,0.9894023,0.00001047224,0.009429731,0.0004423577],"study_design_scores_gemma":[0.00008994981,0.00005413252,0.000492225,0.000005813651,0.000001007577,0.000002070389,0.0002439499,0.0006217071,0.9928964,0.00005137205,0.005453052,0.00008833106],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980844,0.0002533953,0.0001084424,0.0001275093,0.0001495702,0.00006463551,0.000008504813,0.00001170901,0.001191837],"genre_scores_gemma":[0.9956383,0.0002352154,0.00002434137,0.000186726,0.0000253287,0.00001203309,0.000006972244,0.000004801198,0.003866246],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003976679,"threshold_uncertainty_score":0.2618254,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01501845404299636,"score_gpt":0.2591667660947408,"score_spread":0.2441483120517444,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}