{"id":"W4385298686","doi":"10.1126/science.ade6967","title":"In vivo hematopoietic stem cell modification by mRNA delivery","year":2023,"lang":"en","type":"article","venue":"Science","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":304,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"Ionis Pharmaceuticals; National Heart, Lung, and Blood Institute; University of Pennsylvania; National Institutes of Health; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Children's Hospital of Philadelphia","keywords":"Haematopoiesis; Stem cell; In vivo; Biology; Hematopoietic stem cell; CD117; Transplantation; Cell biology; Cancer research; Immunology; CD34; Medicine; Genetics; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001791523,0.0003397345,0.0001768296,0.0001609167,0.0001360593,0.0002631713,0.0001935713,0.0003145564,0.001419037],"category_scores_gemma":[0.0001019858,0.0001075034,0.0001694982,0.00009711726,0.0002744712,0.0001448657,0.0001500584,0.0005061096,0.0004192826],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00028398,"about_ca_system_score_gemma":0.0002029264,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003670462,"about_ca_topic_score_gemma":0.000376185,"domain_scores_codex":[0.999845,0.00002281936,0.000009945396,0.00004966414,0.00004741074,0.0000251271],"domain_scores_gemma":[0.9999433,0.00001278161,0.00001834394,0.000008907254,0.000008160375,0.000008619419],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002445394,0.00001591687,0.0000330023,0.00003662723,0.00000231,0.00003530013,0.0000139985,0.000106598,0.996859,0.0004225152,0.00008753838,0.002362806],"study_design_scores_gemma":[0.000005987275,0.00009342373,0.00008946236,0.000001802389,0.000006014855,0.00005334889,0.000003278366,0.0003880811,0.9967295,0.00003227772,0.002595351,0.000001506702],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8532398,0.004373176,0.1270669,0.0005393054,0.0003152506,0.0004185257,0.0009433568,0.001547011,0.01155672],"genre_scores_gemma":[0.9577107,0.002442538,0.0301726,0.0001729549,0.00003515212,0.0002137751,0.000502156,0.0001147172,0.008635497],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001419037,"threshold_uncertainty_score":0.004747152,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01501845404299636,"score_gpt":0.2591667660947408,"score_spread":0.2441483120517444,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}