{"id":"W4385298954","doi":"10.1016/j.msard.2023.104911","title":"Is it ethical to use teriflunomide as an active comparator in phase 3 trials?","year":2023,"lang":"en","type":"review","venue":"Multiple Sclerosis and Related Disorders","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Public Health Ontario; University of Toronto","funders":"","keywords":"Teriflunomide; Medicine; Clinical trial; Amyotrophic lateral sclerosis; Multiple sclerosis; Family medicine; Disease; Oncology; Fingolimod; Internal medicine; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow","research_integrity"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.002266259,0.001056072,0.005651499,0.001278612,0.0003346102,0.0002283746,0.0003719222,0.001810176,0.0003308558],"category_scores_gemma":[0.009661461,0.0007914468,0.00102401,0.001746662,0.0004214507,0.0002546561,0.0004481303,0.003112074,0.0006601436],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003404086,"about_ca_system_score_gemma":0.0004386512,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001446323,"about_ca_topic_score_gemma":0.00144393,"domain_scores_codex":[0.992342,0.001609821,0.002423903,0.001683143,0.0008593911,0.001081758],"domain_scores_gemma":[0.9936571,0.00368746,0.0005418137,0.0009017217,0.0001780866,0.001033786],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001533616,0.001395047,0.000477446,0.005054127,0.001849541,0.00004251527,0.003886505,0.000007568337,0.0001503706,0.00001345282,0.0101074,0.9754824],"study_design_scores_gemma":[0.02049441,0.001639502,0.01130949,0.03991539,0.001833413,0.00001790477,0.001840166,0.0008168079,0.0000195544,0.00002785417,0.9205735,0.001512008],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.03685805,0.9403046,0.00001043768,0.005893062,0.0007317169,0.013803,0.001447658,0.0004196917,0.0005317999],"genre_scores_gemma":[0.006714615,0.9897999,0.0001602536,0.0007315467,0.00009927696,0.00111013,0.0004865972,0.0002270807,0.0006705881],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9739704,"threshold_uncertainty_score":0.9994857,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3638427763101612,"score_gpt":0.47076212204114,"score_spread":0.1069193457309788,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}