{"id":"W4385298954","doi":"10.1016/j.msard.2023.104911","title":"Is it ethical to use teriflunomide as an active comparator in phase 3 trials?","year":2023,"lang":"en","type":"review","venue":"Multiple Sclerosis and Related Disorders","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Public Health Ontario; University of Toronto","funders":"","keywords":"Teriflunomide; Medicine; Clinical trial; Amyotrophic lateral sclerosis; Multiple sclerosis; Family medicine; Disease; Oncology; Fingolimod; Internal medicine; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.05223897,0.000505249,0.005300761,0.001064526,0.000457412,0.002191388,0.001488851,0.004433628,0.004872247],"category_scores_gemma":[0.08569542,0.0005087376,0.002949585,0.001175813,0.002402133,0.002876271,0.00116849,0.004986607,0.000578835],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00137532,"about_ca_system_score_gemma":0.003722694,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008057327,"about_ca_topic_score_gemma":0.00216493,"domain_scores_codex":[0.9640834,0.02605521,0.005447374,0.001143591,0.00287168,0.0003987616],"domain_scores_gemma":[0.9123957,0.07167889,0.01091866,0.001460338,0.00262903,0.0009173972],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.01106837,0.0001651052,0.001143497,0.1588497,0.007907356,0.000207831,0.000476147,0.0003619863,0.001244812,0.01629423,0.03285266,0.7694283],"study_design_scores_gemma":[0.04452997,0.004909109,0.005990117,0.3205952,0.02624414,0.001697882,0.001056027,0.0009815264,0.001751111,0.04080825,0.5512654,0.0001712333],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002142821,0.9701632,0.001599411,0.01930294,0.00383449,0.0003438558,0.0002346184,0.00001809694,0.002360655],"genre_scores_gemma":[0.1038997,0.8063858,0.0144999,0.06272519,0.007822156,0.002388678,0.0004072179,0.00004580018,0.001825631],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9955664,"threshold_uncertainty_score":0.2762694,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3638427763101612,"score_gpt":0.47076212204114,"score_spread":0.1069193457309788,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}