{"id":"W4385301669","doi":"10.1101/2023.07.26.550660","title":"Interaction of SCoV-2 <i>NSP7</i> or <i>NSP8</i> alone with <i>NSP12</i> causes constriction of the RNA entry channel: Implications for novel RdRp inhibitor drug discovery","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Viral Infections and Immunology Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"All-India Institute of Medical Sciences; Science and Engineering Research Board; Indian Council of Medical Research; Department of Science and Technology, Ministry of Science and Technology, India; Biotechnology Industry Research Assistance Council; Department of Biotechnology, Ministry of Science and Technology, India","keywords":"RNA polymerase; RNA; RNA-dependent RNA polymerase; Polymerase; Biology; Cell biology; Biochemistry; Chemistry; Biophysics; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001144501,0.0003205381,0.0004028989,0.00007163783,0.0002427063,0.0003254355,0.0004627689,0.0003555532,0.001727566],"category_scores_gemma":[0.0001799364,0.0001446916,0.0004649874,0.00009142937,0.000210131,0.0002677267,0.0002207955,0.0005944584,0.0002555056],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003622603,"about_ca_system_score_gemma":0.0002784953,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001933606,"about_ca_topic_score_gemma":0.002022076,"domain_scores_codex":[0.999884,0.00001373701,0.000008711926,0.00002087361,0.0000438111,0.00002879942],"domain_scores_gemma":[0.9999472,0.00001408153,0.00001480644,0.000003840488,0.000006072089,0.00001404184],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004300943,0.0001768757,0.001806172,0.0001841491,0.00008438128,0.0002832781,0.00002969296,0.005538015,0.9879202,0.0006964929,0.0004620112,0.002388646],"study_design_scores_gemma":[0.0001172253,0.000778925,0.005338043,0.00002816836,0.00009594167,0.0003745454,0.0001143,0.09807792,0.8906381,0.000368993,0.004021023,0.00004692741],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967648,0.0005601587,0.001361158,0.00008871167,0.00002575968,0.00001380182,0.0002049273,0.00005184331,0.0009288458],"genre_scores_gemma":[0.9972448,0.0003125872,0.001458981,0.0000534897,0.000003654416,0.00001884624,0.0003973795,0.00001484125,0.0004953392],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001933606,"threshold_uncertainty_score":0.005779326,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03818663965978154,"score_gpt":0.2857939855114393,"score_spread":0.2476073458516578,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}