{"id":"W4385318213","doi":"10.1101/2023.07.24.550252","title":"Protein Assembly Modulation: A New Approach to ALS Therapeutics","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Target ALS","keywords":"Amyotrophic lateral sclerosis; Capsid; Biology; Transgene; Cell biology; Drug discovery; Mechanism (biology); Small molecule; Computational biology; Neuroscience; Gene; Disease; Genetics; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003672239,0.0005730316,0.0004410663,0.0003956849,0.0002782195,0.0008704677,0.0003971099,0.0004791915,0.002412604],"category_scores_gemma":[0.0001431177,0.0002142823,0.0003475641,0.0001748573,0.0005680608,0.0008121104,0.0005569458,0.001271144,0.0007556983],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006135558,"about_ca_system_score_gemma":0.0003173405,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002071581,"about_ca_topic_score_gemma":0.0003175727,"domain_scores_codex":[0.9998723,0.00002863868,0.000008846637,0.00003262223,0.00003934428,0.00001822101],"domain_scores_gemma":[0.999933,0.0000112991,0.00001391488,0.00001072319,0.0000126157,0.00001841438],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000253629,0.0003127863,0.0002096879,0.000421168,0.00004328384,0.0002669588,0.00009673883,0.001006159,0.9169783,0.02198178,0.00266575,0.05576375],"study_design_scores_gemma":[0.0002988625,0.001683904,0.0007304894,0.00007575694,0.00009069893,0.0009440948,0.0000502132,0.005061435,0.7836535,0.00839309,0.198983,0.00003488787],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5090798,0.150927,0.2496208,0.02205275,0.003853225,0.0009549241,0.00113262,0.002460239,0.05991861],"genre_scores_gemma":[0.8036158,0.06852351,0.07699589,0.00410581,0.001094563,0.0004244767,0.0006152267,0.0002072622,0.04441746],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002412604,"threshold_uncertainty_score":0.008071005,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08709988460306603,"score_gpt":0.3030055961186185,"score_spread":0.2159057115155525,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}