{"id":"W4385319865","doi":"10.1101/2023.07.24.550415","title":"Mammalian cells-based platforms for the generation of SARS-CoV-2 virus-like particles","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Université du Québec à Trois-Rivières","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Fondation de l’UQTR; University of Toronto; Université du Québec à Trois-Rivières; Styrelsen för Internationellt Utvecklingssamarbete","keywords":"Virology; Virus; Transduction (biophysics); Transfection; Biology; Viral entry; Viral envelope; Virus-like particle; Coronavirus; HEK 293 cells; Viral structural protein; Cell culture; Coronavirus disease 2019 (COVID-19); Chemistry; Viral replication; Gene; Recombinant DNA; Medicine; Genetics; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002914265,0.0003316158,0.0002362923,0.0001949029,0.0001461707,0.000374499,0.0002758003,0.0004184664,0.001089619],"category_scores_gemma":[0.0001396635,0.0001653298,0.0003194069,0.0001476584,0.0001426745,0.0002252541,0.0002538956,0.0005598921,0.0008033327],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002827233,"about_ca_system_score_gemma":0.0001581319,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001586796,"about_ca_topic_score_gemma":0.0002320047,"domain_scores_codex":[0.9998247,0.00003353921,0.00001653488,0.00003129805,0.00007153599,0.00002241317],"domain_scores_gemma":[0.999954,0.00001004354,0.00001169665,0.000008211722,0.00001016691,0.00000593915],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001510205,0.00001652996,0.00004574559,0.00003631101,0.000004072946,0.000032007,0.00001144397,0.0001342043,0.9985974,0.0002814298,0.00007788677,0.0007477482],"study_design_scores_gemma":[0.00001383549,0.0001883276,0.0003654537,0.000006972932,0.00001101424,0.0001135856,0.00001408774,0.001752303,0.9897601,0.0000887446,0.007680656,0.000004962121],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8647705,0.005301795,0.1166906,0.0004271768,0.0003423179,0.0006317603,0.003539135,0.0006878654,0.007608857],"genre_scores_gemma":[0.9455696,0.00217755,0.0431084,0.0001311436,0.00003106406,0.0003639031,0.003779378,0.00006315114,0.004775863],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001089619,"threshold_uncertainty_score":0.003645182,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1033186846266781,"score_gpt":0.3243491346183373,"score_spread":0.2210304499916591,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}