{"id":"W4385319946","doi":"10.1101/2023.07.25.550461","title":"<i>Leishmania major</i> -induced alteration of host cellular and systemic copper homeostasis drives the fate of infection","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Trace Elements in Health","field":"Nursing","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Science and Engineering Research Board; National Institutes of Health; Department of Science and Technology, Ministry of Science and Technology, India; Council of Scientific and Industrial Research, India; Department of Biotechnology, Ministry of Science and Technology, India; Indian Institute of Science Education and Research Pune; Wellcome Trust; Indian Institute of Science Education and Research Mohali; Canadian Institute for Advanced Research","keywords":"Leishmania; Copper; Amastigote; Macrophage; ATP7A; Cell biology; Pathogen; Homeostasis; Biology; Host (biology); Endocytosis; Microbiology; Virulence; Downregulation and upregulation; ATPase; Chemistry; Parasite hosting; In vitro; Biochemistry; Ecology; Enzyme; Cell","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009606787,0.0002000697,0.0001552362,0.0001218751,0.000102992,0.000274092,0.0001368131,0.0002233433,0.002423535],"category_scores_gemma":[0.00007172512,0.00009890551,0.0001532551,0.00009149836,0.0002097513,0.0001206424,0.0001943052,0.0004105768,0.0007104943],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003200751,"about_ca_system_score_gemma":0.0001352676,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004872952,"about_ca_topic_score_gemma":0.0006051037,"domain_scores_codex":[0.9998811,0.00001855944,0.000006117535,0.00002850025,0.00001757245,0.00004815555],"domain_scores_gemma":[0.9999481,0.000005385296,0.00001440795,0.000007741422,0.000006984367,0.00001727382],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001653834,0.00001866335,0.0001974947,0.00002914598,0.0000025187,0.00007108732,0.00001012447,0.00001633137,0.9984943,0.0001313892,0.0002047242,0.0006590055],"study_design_scores_gemma":[0.00002152647,0.0002957812,0.008682334,0.00001121463,0.000009627905,0.0004324673,0.00007191879,0.000553318,0.9856992,0.0001326998,0.004085079,0.000004814662],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897084,0.001204405,0.002351251,0.0004267498,0.00009435111,0.00003065554,0.0008258095,0.0002024862,0.00515596],"genre_scores_gemma":[0.9909899,0.0003202232,0.0008695758,0.0001506441,0.00001833755,0.00003056161,0.0006276028,0.00003239001,0.006960731],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002423535,"threshold_uncertainty_score":0.008107483,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02184524543616742,"score_gpt":0.2510441583744628,"score_spread":0.2291989129382954,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}