{"id":"W4385324141","doi":"10.1016/j.imlet.2023.07.009","title":"GM-CSF distinctly impacts human monocytes and macrophages via ERK1/2-dependent pathways","year":2023,"lang":"en","type":"article","venue":"Immunology Letters","topic":"Immune responses and vaccinations","field":"Immunology and Microbiology","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Canadian Institutes of Health Research","keywords":"CD80; Cell biology; Monocyte; Myeloid; Secretion; Chemokine; Immune system; Macrophage; CXCL10; Chemistry; Biology; Immunology; CD40; Cytotoxic T cell; Endocrinology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003176461,0.0003192972,0.0003919481,0.0003967271,0.0007447239,0.00005043624,0.0003551604,0.0003158146,0.0005569984],"category_scores_gemma":[0.000114703,0.0002956077,0.0001209547,0.0002755159,0.0004003572,0.0001612893,0.0003391604,0.0005059912,0.001447004],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007201217,"about_ca_system_score_gemma":0.00003071119,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003029715,"about_ca_topic_score_gemma":0.00003915717,"domain_scores_codex":[0.9979789,0.0003332018,0.0003960245,0.0004632733,0.00004334449,0.0007852224],"domain_scores_gemma":[0.9989524,0.0003168987,0.0001563816,0.0004947043,0.00004927433,0.00003033104],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001394295,0.00005586613,0.002988241,0.00001464309,0.0003881933,0.00008794463,0.0005912836,0.000004107427,0.9844547,0.0007633183,0.00507756,0.005434738],"study_design_scores_gemma":[0.004295365,0.0004919132,0.6562881,0.00005315016,0.000141877,0.0007494774,0.0006795563,0.00001256322,0.3161003,0.0007303479,0.01967785,0.0007795498],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883931,0.005328774,0.00009904553,0.0043539,0.0008535738,0.0002681969,0.00006006128,0.0003577739,0.0002855963],"genre_scores_gemma":[0.9965913,0.0003998235,0.00002335496,0.0007065247,0.00003773573,0.00006141077,0.000352868,0.00004143171,0.001785581],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6683544,"threshold_uncertainty_score":0.9999496,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01503099085384102,"score_gpt":0.2521252473957523,"score_spread":0.2370942565419112,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}