{"id":"W4385330523","doi":"10.1161/circinterventions.123.012997","title":"EXACT Trial: Results of the Phase 1 Dose-Escalation Study","year":2023,"lang":"en","type":"article","venue":"Circulation Cardiovascular Interventions","topic":"Cardiac Imaging and Diagnostics","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital","funders":"","keywords":"De-escalation; Phase (matter); Medicine; Physics; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004507235,0.001624894,0.00239487,0.0004103039,0.0002850659,0.001315071,0.0008831599,0.001597153,0.006945423],"category_scores_gemma":[0.00311655,0.0004513956,0.001322027,0.0003914333,0.0008742098,0.001451418,0.0004486238,0.002526204,0.001375953],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000596848,"about_ca_system_score_gemma":0.0009015039,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00026299,"about_ca_topic_score_gemma":0.0005606127,"domain_scores_codex":[0.9986368,0.0007881711,0.00006956729,0.0001780013,0.0001932219,0.0001343523],"domain_scores_gemma":[0.9985507,0.0005089823,0.000419899,0.0001750575,0.00008638636,0.0002590176],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8678725,0.01170533,0.004010527,0.001307932,0.002145753,0.0001538478,0.0001510483,0.00256493,0.008541867,0.000740155,0.007148298,0.09365793],"study_design_scores_gemma":[0.9022265,0.08205295,0.007976697,0.00007635584,0.0006039919,0.0002028353,0.00002222026,0.001437331,0.0006086088,0.0006220516,0.004131079,0.0000392828],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9573016,0.01473086,0.003776554,0.00239091,0.0006061445,0.004996529,0.005054347,0.0005017724,0.01064126],"genre_scores_gemma":[0.953868,0.006570631,0.008032303,0.006070654,0.0009558616,0.006880989,0.007500433,0.0001846708,0.009936417],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006945423,"threshold_uncertainty_score":0.02383679,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08415818595471825,"score_gpt":0.3770272431910696,"score_spread":0.2928690572363514,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}