{"id":"W4385330997","doi":"10.1038/s41590-023-01572-4","title":"Apoptotic contraction drives target cell release by cytotoxic T cells","year":2023,"lang":"en","type":"article","venue":"Nature Immunology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto Metropolitan University","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Canada Research Chairs; National Cancer Institute; National Institutes of Health; U.S. Department of Health and Human Services; Government of Canada; Ludwig Institute for Cancer Research; Memorial Sloan-Kettering Cancer Center; Cancer Research Institute","keywords":"Cytotoxic T cell; Perforin; Cell biology; CTL*; Granzyme; Apoptosis; Intracellular; Immune system; Contraction (grammar); Immunological synapse; Chemistry; Cell; Biology; T cell; Immunology; Biochemistry; T-cell receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001987096,0.0002710572,0.0003677433,0.0001937193,0.0002623994,0.0008422293,0.0002786692,0.0004325896,0.002532202],"category_scores_gemma":[0.0004000886,0.0001921863,0.000211493,0.000122262,0.0002774024,0.000545212,0.0006342106,0.001299928,0.0009250142],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003379731,"about_ca_system_score_gemma":0.0001862272,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008169442,"about_ca_topic_score_gemma":0.0001607551,"domain_scores_codex":[0.999733,0.0000320592,0.000011041,0.00004245814,0.00007161775,0.0001097341],"domain_scores_gemma":[0.9996201,0.0001189876,0.000060382,0.00004740758,0.00005698629,0.00009610564],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006741358,0.00005605441,0.0009051763,0.00005923564,0.000006741676,0.0002263806,0.0000662479,0.0002602069,0.9886945,0.0008548317,0.0002820398,0.007914504],"study_design_scores_gemma":[0.0001457733,0.0007891789,0.0145965,0.0000328742,0.00002605071,0.001032388,0.000348274,0.007626982,0.9689398,0.001397102,0.005050901,0.00001407302],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935409,0.00102525,0.002306846,0.0001787096,0.00007033925,0.00001161502,0.00004610415,0.00005855727,0.002761618],"genre_scores_gemma":[0.9967007,0.0002496514,0.0005911823,0.00006288743,0.00003304666,0.0000100766,0.00009743922,0.00002349777,0.002231504],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002532202,"threshold_uncertainty_score":0.008471072,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003720876785563344,"score_gpt":0.2237869567175823,"score_spread":0.2200660799320189,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}