{"id":"W4385330997","doi":"10.1038/s41590-023-01572-4","title":"Apoptotic contraction drives target cell release by cytotoxic T cells","year":2023,"lang":"en","type":"article","venue":"Nature Immunology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto Metropolitan University","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Canada Research Chairs; National Cancer Institute; National Institutes of Health; U.S. Department of Health and Human Services; Government of Canada; Ludwig Institute for Cancer Research; Memorial Sloan-Kettering Cancer Center; Cancer Research Institute","keywords":"Cytotoxic T cell; Perforin; Cell biology; CTL*; Granzyme; Apoptosis; Intracellular; Immune system; Contraction (grammar); Immunological synapse; Chemistry; Cell; Biology; T cell; Immunology; Biochemistry; T-cell receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0003873988,0.0004351205,0.0005642449,0.0004292805,0.0004768854,0.00003324803,0.0005718409,0.00195682,0.00156686],"category_scores_gemma":[0.0001808187,0.0004050589,0.0002453139,0.0006085465,0.0004643451,0.0002239392,0.0001251795,0.002197508,0.00778108],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009489891,"about_ca_system_score_gemma":0.0001216326,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004782611,"about_ca_topic_score_gemma":0.000002040806,"domain_scores_codex":[0.9971111,0.0007164975,0.0005195754,0.0005915186,0.00007225743,0.00098906],"domain_scores_gemma":[0.9982588,0.0006533917,0.000267252,0.0006784378,0.0001137783,0.00002835896],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001149514,0.0002173665,0.00007008939,0.00001438639,0.000323318,0.000020218,0.0002492814,0.000009699727,0.9305208,0.0002108592,0.06437653,0.00283795],"study_design_scores_gemma":[0.001935018,0.0003173313,0.001353082,0.0000176698,0.00002986135,0.00005880526,0.0002613894,0.000005395965,0.6670236,0.0001194272,0.3285733,0.0003051535],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.914085,0.07608139,0.0001036064,0.00103857,0.005888437,0.0005448352,0.0001375818,0.0007823049,0.001338301],"genre_scores_gemma":[0.9663069,0.004565709,0.00005785028,0.0007080059,0.00005500158,0.0000731159,0.000739845,0.00007288896,0.02742065],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2641967,"threshold_uncertainty_score":0.9998401,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003720876785563344,"score_gpt":0.2237869567175823,"score_spread":0.2200660799320189,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}