{"id":"W4385335039","doi":"10.1101/2023.07.25.23293180","title":"Time-to-Event Genome-Wide Association Study for Incident Cardiovascular Disease in People with Type 2 Diabetes Mellitus","year":2023,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Office of Research Infrastructure Programs, National Institutes of Health; National Institute on Minority Health and Health Disparities; National Center for Advancing Translational Sciences; National Human Genome Research Institute; University of Pennsylvania Health System; National Heart, Lung, and Blood Institute; National Institute on Aging; Korea Health Industry Development Institute; Perelman School of Medicine, University of Pennsylvania; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; European Commission; American Diabetes Association; Mississippi State Department of Health; Georgia Clinical and Translational Science Alliance; University of Pennsylvania; National Institute of Diabetes and Digestive and Kidney Diseases; Jackson State University; National Institutes of Health; Regeneron Pharmaceuticals; Fred Hutchinson Cancer Research Center; Bristol-Myers Squibb; U.S. Department of Veterans Affairs; American Heart Association; U.S. Department of Health and Human Services","keywords":"Hazard ratio; Genome-wide association study; Medicine; Type 2 diabetes; Proportional hazards model; Type 2 Diabetes Mellitus; Internal medicine; Disease; Diabetes mellitus; Coronary artery disease; Cohort; Cohort study; Confidence interval; Genetics; Single-nucleotide polymorphism; Biology; Endocrinology; Gene; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003227411,0.0006016097,0.001421201,0.0009980814,0.0007290647,0.001132592,0.0008503388,0.001180703,0.001997878],"category_scores_gemma":[0.007242634,0.0004615403,0.004206832,0.003072416,0.00032742,0.0004609821,0.0007472781,0.001812572,0.0001726446],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003506364,"about_ca_system_score_gemma":0.0005916308,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006524604,"about_ca_topic_score_gemma":0.007061478,"domain_scores_codex":[0.9967915,0.001045192,0.0003547298,0.001231753,0.0003496705,0.0002270421],"domain_scores_gemma":[0.9960873,0.001668687,0.001011323,0.0005808028,0.0003720766,0.0002798096],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00228035,0.00006525929,0.9789829,0.0002212094,0.01368907,0.0002268681,0.00006778557,0.0003552828,0.0004603534,0.0001687959,0.0005010432,0.002981],"study_design_scores_gemma":[0.0004712822,0.0002923041,0.9865959,0.00006066923,0.009028817,0.000394754,0.00006232025,0.001329052,0.0001519803,0.0005477254,0.0010463,0.00001878284],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9668106,0.01591812,0.005756214,0.0007597978,0.0004717627,0.0001321404,0.008257397,0.0001241144,0.001769805],"genre_scores_gemma":[0.9926271,0.001892431,0.001547291,0.0002628964,0.0001397777,0.0001626047,0.002898821,0.00001970319,0.0004494326],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006524604,"threshold_uncertainty_score":0.01706839,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01341110887459139,"score_gpt":0.2519974417378231,"score_spread":0.2385863328632317,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}