{"id":"W4385335333","doi":"10.1093/infdis/jiad293","title":"Drug Resistance Assessed in a Phase 3 Clinical Trial of Maribavir Therapy for Refractory or Resistant Cytomegalovirus Infection in Transplant Recipients","year":2023,"lang":"en","type":"article","venue":"The Journal of Infectious Diseases","topic":"Cytomegalovirus and herpesvirus research","field":"Medicine","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Institutes of Health; Danmarks Grundforskningsfond; Cidara Therapeutics; National Research Foundation; U.S. Department of Veterans Affairs","keywords":"Refractory (planetary science); Drug resistance; Medicine; Cytomegalovirus; Clinical trial; Virology; Drug; Internal medicine; Immunology; Pharmacology; Viral disease; Herpesviridae; Virus; Biology; Microbiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002813548,0.0007864801,0.001256199,0.0002796529,0.0003793218,0.0007047669,0.0005081134,0.0006491294,0.00272711],"category_scores_gemma":[0.001543573,0.0003724078,0.00123583,0.0002569111,0.0005855539,0.0004417422,0.0002823715,0.001925629,0.0004100032],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007642501,"about_ca_system_score_gemma":0.0009925985,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004674238,"about_ca_topic_score_gemma":0.0009074057,"domain_scores_codex":[0.999113,0.0005517086,0.00004569345,0.00008944296,0.00006776653,0.0001323007],"domain_scores_gemma":[0.9987385,0.0002947115,0.0004098139,0.00009554943,0.00006570092,0.0003957847],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8681902,0.03394562,0.0215802,0.0003652025,0.001176913,0.0001931716,0.0002117239,0.0013482,0.03304806,0.0001153282,0.00090095,0.03892437],"study_design_scores_gemma":[0.4351978,0.5151784,0.03980995,0.00003411755,0.0007959789,0.0003087645,0.00006097275,0.001787639,0.005497705,0.000115922,0.001184025,0.00002863519],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987469,0.0003927831,0.00011248,0.0000681251,0.00001823535,0.0003482719,0.00009800748,0.00001346128,0.0002017556],"genre_scores_gemma":[0.9982339,0.0002127878,0.0004362873,0.0001320423,0.00003920321,0.0004389506,0.000258856,0.000005899205,0.0002420567],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002813548,"threshold_uncertainty_score":0.01487964,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07718999608805939,"score_gpt":0.4236884161707953,"score_spread":0.3464984200827359,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}