{"id":"W4385342450","doi":"10.3390/ph16081072","title":"Synthesis and Evaluation of ePSMA-DM1: A New Theranostic Small-Molecule Drug Conjugate (T-SMDC) for Prostate Cancer","year":2023,"lang":"en","type":"article","venue":"Pharmaceuticals","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"TRIUMF","funders":"Erasmus Medisch Centrum","keywords":"Conjugate; Prostate cancer; Chemistry; Small molecule; Cancer research; Prodrug; Linker; Glutamate carboxypeptidase II; Pharmacology; Biophysics; Medicine; Cancer; Biochemistry; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008564551,0.0001662527,0.000317219,0.0000599391,0.00008278476,0.00001730648,0.00008588756,0.00005862807,0.0003971358],"category_scores_gemma":[0.0005844299,0.0001459829,0.00009121036,0.0003317392,0.0001421464,0.00003991567,0.00003331988,0.0001375204,0.00002967045],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004883838,"about_ca_system_score_gemma":0.0002473718,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001904387,"about_ca_topic_score_gemma":0.000001603046,"domain_scores_codex":[0.9986127,0.00007009341,0.0003395104,0.0003328808,0.0003228984,0.0003219293],"domain_scores_gemma":[0.9983733,0.0007522978,0.00008367085,0.0002008475,0.0002408534,0.0003490066],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005537784,0.0001669336,0.001375784,0.0009002739,0.0002971473,0.000004447182,0.0004273569,0.0001035786,0.9135186,0.0003615238,0.004050745,0.07823981],"study_design_scores_gemma":[0.003052688,0.00002739642,0.001241927,0.0001577292,0.001592796,0.000009234516,0.00006892181,0.04196726,0.9404161,0.001057079,0.01024305,0.0001658248],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9794458,0.002443899,0.0001355424,0.01447283,0.00006487388,0.002092362,0.0001296764,0.0001177179,0.001097309],"genre_scores_gemma":[0.9957255,0.000942501,0.0002620361,0.0006305102,0.000160858,0.001077858,0.00003070025,0.00003368335,0.001136332],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07807399,"threshold_uncertainty_score":0.595301,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1435657389808254,"score_gpt":0.443154364305439,"score_spread":0.2995886253246136,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}