{"id":"W4385342906","doi":"10.1021/acsomega.3c02172","title":"Grafting Strategies of Oxidation-Prone Coiled-Coil Peptides for Protein Capture in Bioassays: Impact of Orientation and the Oxidation State","year":2023,"lang":"en","type":"article","venue":"ACS Omega","topic":"Advanced Biosensing Techniques and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Polytechnique Montréal","funders":"Institut TransMedTech; Natural Sciences and Engineering Research Council of Canada; Canada First Research Excellence Fund","keywords":"Covalent bond; Cysteine; Chemistry; Bioorthogonal chemistry; Amine gas treating; Thiol; Carbodiimide; Combinatorial chemistry; Peptide; Residue (chemistry); Click chemistry; Polymer chemistry; Biochemistry; Organic chemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002372975,0.00006915897,0.00009593433,0.00004451802,0.00004022865,0.00001191583,0.00005699907,0.00004827361,1.451737e-7],"category_scores_gemma":[0.0001005525,0.00004986694,0.0000354047,0.0001879719,0.0001110166,0.00001102337,0.00003070535,0.0000323573,1.559166e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007950973,"about_ca_system_score_gemma":0.00004130155,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001407988,"about_ca_topic_score_gemma":0.00009044812,"domain_scores_codex":[0.9995084,0.00002403504,0.0001871363,0.0001359008,0.00005379194,0.0000907014],"domain_scores_gemma":[0.9995489,0.0000279109,0.0001603575,0.0001438181,0.0001075709,0.00001144396],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008582971,0.00001309455,0.0003532193,0.00002964841,0.0000135004,6.646835e-8,0.0001535636,0.0002480586,0.9955178,0.001952594,0.00006870594,0.001563955],"study_design_scores_gemma":[0.0007666162,0.0001384359,0.005620234,0.00003373012,0.000009191731,0.000001026449,0.0007833564,0.0004265067,0.9808018,0.01123961,0.0001026323,0.00007683277],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922174,0.00006161036,0.006914037,0.0001452706,0.000005980222,0.0005648991,0.00003730458,0.0000134445,0.00004003386],"genre_scores_gemma":[0.9961045,0.0001040411,0.003327775,0.000006119555,0.00001443696,0.0001071378,0.0002711863,0.000008391637,0.00005636853],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01471594,"threshold_uncertainty_score":0.2033515,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01157382355349963,"score_gpt":0.3036232074808459,"score_spread":0.2920493839273463,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}