{"id":"W4385342906","doi":"10.1021/acsomega.3c02172","title":"Grafting Strategies of Oxidation-Prone Coiled-Coil Peptides for Protein Capture in Bioassays: Impact of Orientation and the Oxidation State","year":2023,"lang":"en","type":"article","venue":"ACS Omega","topic":"Advanced Biosensing Techniques and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Polytechnique Montréal","funders":"Institut TransMedTech; Natural Sciences and Engineering Research Council of Canada; Canada First Research Excellence Fund","keywords":"Covalent bond; Cysteine; Chemistry; Bioorthogonal chemistry; Amine gas treating; Thiol; Carbodiimide; Combinatorial chemistry; Peptide; Residue (chemistry); Click chemistry; Polymer chemistry; Biochemistry; Organic chemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001636576,0.0003658618,0.0001618429,0.0001505143,0.0001370708,0.0003341999,0.0002020452,0.000334771,0.0004279626],"category_scores_gemma":[0.000177715,0.00009368218,0.0001454775,0.0001493728,0.0001926253,0.0003306454,0.0001916205,0.0002724355,0.0001798703],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000133877,"about_ca_system_score_gemma":0.00008993789,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002384073,"about_ca_topic_score_gemma":0.0004595514,"domain_scores_codex":[0.9998543,0.00002389424,0.00001351636,0.00003187866,0.00004336552,0.00003303048],"domain_scores_gemma":[0.9999104,0.00002291841,0.00002898947,0.00001028448,0.00001519376,0.00001229098],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002781892,0.00001863064,0.0001173681,0.00003945499,0.000003233852,0.00002174208,0.00002261826,0.0001094557,0.9982892,0.0000473436,0.000008587437,0.001294655],"study_design_scores_gemma":[0.000002230832,0.00009473271,0.0005219259,0.000002550509,0.000005499101,0.00006356675,0.0000220124,0.0004635352,0.9982857,0.00001758533,0.0005168264,0.000003777412],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932503,0.001052916,0.004828384,0.00003963798,0.00001573906,0.00002847628,0.00004154654,0.00002616754,0.0007168034],"genre_scores_gemma":[0.9896159,0.001516501,0.007522403,0.00006824198,0.000008679164,0.00002735761,0.0001189039,0.00001611097,0.001105699],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004279626,"threshold_uncertainty_score":0.001431644,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01157382355349963,"score_gpt":0.3036232074808459,"score_spread":0.2920493839273463,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}