{"id":"W4385346774","doi":"10.3390/cells12151949","title":"Treating Hyperexcitability in Human Cerebral Organoids Resulting from Oxygen-Glucose Deprivation","year":2023,"lang":"en","type":"article","venue":"Cells","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"Canada First Research Excellence Fund; Mitacs; Epilepsy Canada; Natural Sciences and Engineering Research Council of Canada; Fondation Brain Canada; University of Toronto; Ontario Centres of Excellence","keywords":"Organoid; Epilepsy; Neuroscience; Human brain; Drug development; Drug discovery; Drug; Mechanism (biology); Bumetanide; Medicine; Pharmacology; Biology; Bioinformatics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000211208,0.0002626292,0.000245105,0.0002116576,0.0001934836,0.0003447082,0.0001676547,0.0002836012,0.001234046],"category_scores_gemma":[0.0001327136,0.00009595462,0.0003114063,0.0001931321,0.0002765128,0.000212455,0.0002839537,0.0006093779,0.0003381083],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002623856,"about_ca_system_score_gemma":0.0002421227,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001433247,"about_ca_topic_score_gemma":0.002439082,"domain_scores_codex":[0.9998448,0.00002098394,0.0000145502,0.00004467873,0.00004774541,0.00002719603],"domain_scores_gemma":[0.9998876,0.00002786654,0.0000215929,0.00002328617,0.0000199075,0.00001976322],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002383897,0.00003667548,0.000332437,0.0001133533,0.00001576911,0.0002724733,0.0001128535,0.0008912898,0.994865,0.0002701147,0.0002054877,0.002646164],"study_design_scores_gemma":[0.0000175625,0.000361613,0.003332005,0.00002266563,0.00003464052,0.0003701637,0.0001857769,0.00149687,0.9858057,0.000157256,0.00820014,0.00001569562],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9576283,0.003354599,0.02893619,0.0002731757,0.000221692,0.0001589045,0.001914197,0.0002109742,0.007302048],"genre_scores_gemma":[0.9824973,0.001918217,0.01004168,0.0001191723,0.000007898678,0.0002439829,0.001241832,0.00003002317,0.003899965],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001433247,"threshold_uncertainty_score":0.004128337,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0733641428762212,"score_gpt":0.3440061167197095,"score_spread":0.2706419738434883,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}