{"id":"W4385346774","doi":"10.3390/cells12151949","title":"Treating Hyperexcitability in Human Cerebral Organoids Resulting from Oxygen-Glucose Deprivation","year":2023,"lang":"en","type":"article","venue":"Cells","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"Canada First Research Excellence Fund; Mitacs; Epilepsy Canada; Natural Sciences and Engineering Research Council of Canada; Fondation Brain Canada; University of Toronto; Ontario Centres of Excellence","keywords":"Organoid; Epilepsy; Neuroscience; Human brain; Drug development; Drug discovery; Drug; Mechanism (biology); Bumetanide; Medicine; Pharmacology; Biology; Bioinformatics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000488656,0.0001472427,0.000172506,0.0002525472,0.0003735674,0.00007949868,0.0004819441,0.00007242041,0.0002512442],"category_scores_gemma":[0.001125055,0.0001449753,0.00004685879,0.001624114,0.0002031518,0.0002822876,0.0002851562,0.0003953025,0.0007091612],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006137542,"about_ca_system_score_gemma":0.00005098835,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001172904,"about_ca_topic_score_gemma":0.00002039324,"domain_scores_codex":[0.9974879,0.0004280065,0.0003311958,0.0008188668,0.0003557475,0.0005782623],"domain_scores_gemma":[0.9985637,0.000880392,0.00007329378,0.000349822,0.00002452606,0.0001082466],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001919029,0.00006933192,0.0179952,0.000007582286,4.598989e-7,0.0001235109,0.0002949299,0.00009723152,0.9804406,0.00002093734,0.0002217446,0.0007092785],"study_design_scores_gemma":[0.0005705524,0.00004929017,0.05393351,0.00000894741,0.000002049122,0.000001743884,0.00006414738,0.004153974,0.9405915,0.0003277916,0.0001721625,0.0001243466],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979724,0.000004299899,0.000003542299,0.0002594793,0.0003242176,0.0002871586,0.0000244902,0.0001866033,0.0009377841],"genre_scores_gemma":[0.9986311,0.00002472362,0.00002132342,0.000484965,0.00009997611,0.00002308663,0.000003819722,0.00002426299,0.0006867634],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03984911,"threshold_uncertainty_score":0.911507,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0733641428762212,"score_gpt":0.3440061167197095,"score_spread":0.2706419738434883,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}