{"id":"W4385351242","doi":"10.1016/j.jtct.2023.07.021","title":"Pilot Study of Donor-Engrafted Clonal Hematopoiesis Evolution and Clinical Outcomes in Allogeneic Hematopoietic Cell Transplantation Recipients Using a National Registry","year":2023,"lang":"en","type":"article","venue":"Transplantation and Cellular Therapy","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; Office of Naval Research; Legend Biotech; Pharmacyclics; Takeda Oncology; U.S. Navy; Health Resources and Services Administration; MorphoSys; BeiGene; Astellas Pharma; Adaptive Biotechnologies; Kiadis Pharma; bluebird bio; TG Therapeutics; Jazz Pharmaceuticals; Swedish Orphan Biovitrum; Omeros Corporation; Vertex Pharmaceuticals; StemCyte; Bentham-Moxon Trust; HistoGenetics; U.S. Department of Defense; Moffitt Cancer Center; Sanofi; GlaxoSmithKline; CSL Behring; Bristol-Myers Squibb; AstraZeneca; Mallinckrodt Pharmaceuticals; Astellas Pharma US; Amgen; Actinium Pharmaceuticals; CareDx; National Heart, Lung, and Blood Institute; Novartis Pharmaceuticals Corporation; Incyte; Pfizer; Comprehensive Cancer Center, City of Hope; American Cancer Society; Atara Biotherapeutics; National Cancer Institute; Gilead Sciences","keywords":"Medicine; Transplantation; Internal medicine; Sibling; Hematopoietic stem cell transplantation; Haematopoiesis; Myeloid; Oncology; Bone marrow; Immunology; Stem cell; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004140319,0.0003228004,0.0004216615,0.001850302,0.001139097,0.001140703,0.0005935822,0.0003657507,0.001485868],"category_scores_gemma":[0.005971444,0.0002374607,0.0004968752,0.00234077,0.0006713105,0.001357124,0.001508859,0.0006199592,0.0004219245],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000849573,"about_ca_system_score_gemma":0.00155501,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003729482,"about_ca_topic_score_gemma":0.0042693,"domain_scores_codex":[0.9976723,0.001086234,0.0002669476,0.0003760275,0.000283606,0.0003147872],"domain_scores_gemma":[0.9929355,0.001564085,0.002577674,0.0008763522,0.001110608,0.0009357393],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002007159,0.0001898016,0.9982016,0.000004214783,0.00001589738,0.00005023989,0.0001845792,0.00003512344,0.0001884592,0.00003234526,0.00004601061,0.0008509902],"study_design_scores_gemma":[0.00003716673,0.001046986,0.996062,0.000007683309,0.00005361996,0.0003352483,0.001313226,0.0003746462,0.0003946365,0.00003976357,0.0003255,0.000009553502],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992309,0.00001413903,0.0001366027,0.00001176925,0.000002052004,0.00003461419,0.0002850759,0.000003004688,0.0002819206],"genre_scores_gemma":[0.9987875,0.00002418896,0.0002673893,0.00001369522,0.000006325817,0.000061433,0.0007392063,0.000003873324,0.00009647271],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004140319,"threshold_uncertainty_score":0.02189636,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06768955839996793,"score_gpt":0.3318854805210957,"score_spread":0.2641959221211277,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}