{"id":"W4385351242","doi":"10.1016/j.jtct.2023.07.021","title":"Pilot Study of Donor-Engrafted Clonal Hematopoiesis Evolution and Clinical Outcomes in Allogeneic Hematopoietic Cell Transplantation Recipients Using a National Registry","year":2023,"lang":"en","type":"article","venue":"Transplantation and Cellular Therapy","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; Office of Naval Research; Legend Biotech; Pharmacyclics; Takeda Oncology; U.S. Navy; Health Resources and Services Administration; MorphoSys; BeiGene; Astellas Pharma; Adaptive Biotechnologies; Kiadis Pharma; bluebird bio; TG Therapeutics; Jazz Pharmaceuticals; Swedish Orphan Biovitrum; Omeros Corporation; Vertex Pharmaceuticals; StemCyte; Bentham-Moxon Trust; HistoGenetics; U.S. Department of Defense; Moffitt Cancer Center; Sanofi; GlaxoSmithKline; CSL Behring; Bristol-Myers Squibb; AstraZeneca; Mallinckrodt Pharmaceuticals; Astellas Pharma US; Amgen; Actinium Pharmaceuticals; CareDx; National Heart, Lung, and Blood Institute; Novartis Pharmaceuticals Corporation; Incyte; Pfizer; Comprehensive Cancer Center, City of Hope; American Cancer Society; Atara Biotherapeutics; National Cancer Institute; Gilead Sciences","keywords":"Medicine; Transplantation; Internal medicine; Sibling; Hematopoietic stem cell transplantation; Haematopoiesis; Myeloid; Oncology; Bone marrow; Immunology; Stem cell; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009047919,0.0002851053,0.000592503,0.0004996042,0.0001090889,0.00002288127,0.0000823599,0.0001272845,0.00002743294],"category_scores_gemma":[0.00001516149,0.000268851,0.00009406528,0.0005605725,0.0001179859,0.0001443911,0.00000608448,0.0002226271,0.000006703525],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005718608,"about_ca_system_score_gemma":0.0001160996,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000299814,"about_ca_topic_score_gemma":0.0001801847,"domain_scores_codex":[0.997211,0.0003098319,0.0010329,0.0005133502,0.0006579461,0.0002750136],"domain_scores_gemma":[0.9989251,0.000387144,0.0002283795,0.0001873002,0.0001308438,0.0001411675],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002579558,0.001880517,0.9123468,0.0009634056,0.000176173,0.0001836181,0.004989932,0.0001493471,0.07635735,0.0001353561,0.000004564421,0.0002333987],"study_design_scores_gemma":[0.01590191,0.001646966,0.9677572,0.0003373616,0.0003359547,0.0002134012,0.001587521,0.001064288,0.01059259,0.0002553572,0.000003529585,0.0003038898],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958646,0.0002260566,0.002238944,0.00007800458,0.0001474503,0.001173114,0.00005962591,0.00008232,0.0001298774],"genre_scores_gemma":[0.9960118,0.002937982,0.0005233,0.00005910087,0.0000284909,0.00004670098,0.0002841274,0.00003872798,0.00006980509],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06576476,"threshold_uncertainty_score":0.9999764,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06768955839996793,"score_gpt":0.3318854805210957,"score_spread":0.2641959221211277,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}