{"id":"W4385351665","doi":"10.1016/j.immuni.2023.07.002","title":"Ketolysis drives CD8+ T cell effector function through effects on histone acetylation","year":2023,"lang":"en","type":"article","venue":"Immunity","topic":"Diet and metabolism studies","field":"Medicine","cited_by":124,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; National Institute on Aging; National Cancer Institute; National Institutes of Health","keywords":"Acetylation; Effector; Biology; Histone; Cell biology; Function (biology); CD8; Cancer research; Immunology; Genetics; Immune system; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001327596,0.000234134,0.000161775,0.0001631648,0.0001434391,0.0003937165,0.0001311737,0.0001617145,0.001818333],"category_scores_gemma":[0.0001090576,0.0001185636,0.0001679286,0.0001456627,0.0001974006,0.0002579164,0.0002332924,0.0003941006,0.0002598488],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002168225,"about_ca_system_score_gemma":0.0001276742,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003654931,"about_ca_topic_score_gemma":0.001144636,"domain_scores_codex":[0.9999062,0.00001871382,0.000006566665,0.00003065467,0.00001521589,0.00002260314],"domain_scores_gemma":[0.9999489,0.000007388021,0.00001302749,0.000005007058,0.00000978485,0.00001599093],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004398876,0.00002435868,0.001570027,0.00006129772,0.00001181481,0.00003633523,0.00002171565,0.00003691295,0.9943751,0.00009375389,0.00004207117,0.003286682],"study_design_scores_gemma":[0.00004429178,0.0006943478,0.04160455,0.00002925599,0.00006741824,0.0002597308,0.0001887809,0.0005828303,0.9518911,0.0003133035,0.004312875,0.00001161228],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921424,0.003218271,0.002244796,0.0001721582,0.00005731345,0.00001737706,0.0003475616,0.00004314508,0.001756996],"genre_scores_gemma":[0.9949822,0.00153296,0.001427287,0.0001092056,0.00002043868,0.00001698756,0.0002169906,0.00001202619,0.001681895],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001818333,"threshold_uncertainty_score":0.006082892,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01895954833887396,"score_gpt":0.2944871890469477,"score_spread":0.2755276407080737,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}