{"id":"W4385368116","doi":"10.1016/j.anai.2023.07.017","title":"Real-world severe asthma biologic administration and adherence differs by biologic","year":2023,"lang":"en","type":"article","venue":"Annals of Allergy Asthma & Immunology","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"AstraZeneca (Canada)","funders":"Baxalta; AstraZeneca; CSL Behring; Genentech; Grifols; Valeant Pharmaceuticals International; Sanofi; Mylan; GlaxoSmithKline; Regeneron Pharmaceuticals; Teva Pharmaceutical Industries; Horizon Pharma; Pfizer","keywords":"Medicine; Mepolizumab; Omalizumab; Dosing; Dupilumab; Benralizumab; Asthma; Pharmacy; Internal medicine; Allergic asthma; Mallinckrodt; Family medicine; Immunology; Eosinophil; Immunoglobulin E","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002283649,0.0001561538,0.0002709856,0.0005797501,0.0003737659,0.00118373,0.0003469028,0.0005876239,0.001704851],"category_scores_gemma":[0.01034946,0.0001542745,0.0005789807,0.001045476,0.0003656805,0.0007026701,0.0005853248,0.0007143292,0.0002791556],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000597371,"about_ca_system_score_gemma":0.0003792826,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005354438,"about_ca_topic_score_gemma":0.006908198,"domain_scores_codex":[0.9956365,0.001947441,0.0008211415,0.0005119527,0.0008041411,0.0002788361],"domain_scores_gemma":[0.987063,0.002542718,0.008543103,0.0005833674,0.0007708436,0.0004969902],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001159632,0.00006669526,0.9949174,0.00003382918,0.0001239496,0.00002391055,0.000212907,0.0001196201,0.00008014782,0.0000433288,0.0002486291,0.004013654],"study_design_scores_gemma":[0.00001046571,0.00009743931,0.998317,0.00003083441,0.00003467834,0.0001469524,0.0003055689,0.0004905331,0.00004690812,0.000062663,0.000450097,0.000006860464],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966,0.0007051352,0.000253041,0.0003109064,0.000009260039,0.00002358497,0.0007951037,0.000005458758,0.001297561],"genre_scores_gemma":[0.9990527,0.0001662691,0.0001396979,0.0000763736,0.00001191117,0.0000161517,0.00047554,0.000001987257,0.00005926273],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005354438,"threshold_uncertainty_score":0.01207721,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04010519612416014,"score_gpt":0.3235910765386775,"score_spread":0.2834858804145174,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}