{"id":"W4385376011","doi":"10.1101/2023.07.28.550963","title":"Epidermal IL-33 drives inflammation in necroptosis-induced skin inflammation by recruiting TNF-producing immune cells","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"IL-33, ST2, and ILC Pathways","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Medical Research Council; University of California, San Diego; Versus Arthritis; Universität Basel; UK Research and Innovation; Institut National de la Santé et de la Recherche Médicale; Cardiff University","keywords":"Necroptosis; Inflammation; Immune system; Epidermis (zoology); Proinflammatory cytokine; Tumor necrosis factor alpha; Immunology; Programmed cell death; Inflammasome; Biology; Cell biology; Apoptosis; Cancer research; Anatomy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002105858,0.0009955873,0.001230571,0.0008611424,0.0005085206,0.0002248985,0.0008572697,0.001775005,0.00005414878],"category_scores_gemma":[0.00113828,0.001158217,0.0002731712,0.0009466068,0.0001947945,0.0005365442,0.0008424277,0.002159569,0.0009978877],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005373181,"about_ca_system_score_gemma":0.00072074,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007198092,"about_ca_topic_score_gemma":0.0000502764,"domain_scores_codex":[0.99396,0.0008914039,0.00186746,0.001751582,0.0002114875,0.001318036],"domain_scores_gemma":[0.9960784,0.0003065641,0.001359837,0.00160811,0.0005395582,0.0001074749],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006418773,0.00007553181,0.001457628,0.0005470464,0.000224807,0.00002819537,0.0003911549,0.0002044266,0.9963303,0.000145763,0.0004508075,0.00008019171],"study_design_scores_gemma":[0.001128745,0.00007261259,0.03846468,0.001029743,0.00009898809,8.177896e-8,0.00006240558,0.00009818046,0.9496974,0.000007084076,0.008216701,0.00112342],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898548,0.0006518301,0.0004258782,0.0002853178,0.004188342,0.001560579,0.002153774,0.0008544721,0.00002500116],"genre_scores_gemma":[0.9972202,0.0006179134,0.0006096508,0.00004779685,0.0006888892,0.0004739904,0.00003840592,0.0002383187,0.00006488426],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0466329,"threshold_uncertainty_score":0.9997799,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0201305676959143,"score_gpt":0.2229160888335436,"score_spread":0.2027855211376293,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}