{"id":"W4385378257","doi":"10.1016/j.hlc.2023.06.374","title":"Effect of Inclisiran on Haematological and Immunological Biomarkers: A Pooled Analysis of ORION-9, -10 and -11 Trial Data","year":2023,"lang":"en","type":"article","venue":"Heart Lung and Circulation","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Michael's Hospital","funders":"","keywords":"Placebo; Dosing; Medicine; Internal medicine; Adverse effect; Gastroenterology; Platelet; White blood cell; Population; Immunology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004068413,0.00007869666,0.000248973,0.0001082001,0.0000397467,0.00001083404,0.00005133472,0.000127981,0.000009013638],"category_scores_gemma":[0.0001485074,0.00005978815,0.00004668198,0.0001916805,0.00008317157,0.000005514614,0.0001080047,0.00002983728,6.525162e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000001888476,"about_ca_system_score_gemma":0.000007747953,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003047267,"about_ca_topic_score_gemma":0.000008964568,"domain_scores_codex":[0.9992614,0.0001371966,0.0001789523,0.0002673653,0.0000741981,0.00008092919],"domain_scores_gemma":[0.9995736,0.00008619802,0.00005819352,0.000229282,0.00002588549,0.000026799],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01241296,0.0001037522,0.2173754,0.0001729427,0.001684024,0.000005495876,0.00009237649,0.00009301413,0.7516338,0.00007523995,0.0005782015,0.01577274],"study_design_scores_gemma":[0.01149704,0.005329709,0.9084749,0.00009387491,0.001727129,0.0000230627,0.000114572,0.03329393,0.03861406,0.00006342668,0.0004603481,0.0003079349],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989129,0.0007652355,0.00003271574,0.00005089618,0.0000282098,0.0001513864,0.0000293553,0.000006827858,0.00002252809],"genre_scores_gemma":[0.9993017,0.0002163213,0.00001147831,0.00001466389,0.00001956316,0.000004967008,0.0004175753,0.000003106953,0.00001062764],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7130198,"threshold_uncertainty_score":0.243809,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02756733903878214,"score_gpt":0.3237539433270751,"score_spread":0.296186604288293,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}