{"id":"W4385378265","doi":"10.1016/j.hlc.2023.06.409","title":"Pooled Safety and Efficacy of Inclisiran in Patients With Statin Intolerance (ORION-10 and ORION-11)","year":2023,"lang":"en","type":"article","venue":"Heart Lung and Circulation","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Tolerability; Placebo; Medicine; myalgia; Statin; Adverse effect; Internal medicine; Clinical endpoint; Surrogate endpoint; Clinical trial; Gastroenterology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008005902,0.001786964,0.00453016,0.0009764462,0.0002802946,0.001875079,0.0007835765,0.001375795,0.002781295],"category_scores_gemma":[0.006720248,0.0007927495,0.01127352,0.00106885,0.0006171733,0.001210782,0.001010733,0.001965398,0.0006356382],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008322135,"about_ca_system_score_gemma":0.0009832676,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00157013,"about_ca_topic_score_gemma":0.00345543,"domain_scores_codex":[0.9965376,0.001809146,0.000486491,0.000525107,0.0003312424,0.0003105479],"domain_scores_gemma":[0.9963496,0.001220983,0.001110733,0.0005337483,0.0004328184,0.000352097],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.8654696,0.0004458512,0.01673657,0.0025128,0.08385392,0.0001064277,0.00006392432,0.0006900643,0.002517794,0.00009747303,0.001350075,0.02615556],"study_design_scores_gemma":[0.3981596,0.08126099,0.2659942,0.001070624,0.2412816,0.0004287041,0.0002636755,0.001650403,0.003100743,0.0006591039,0.005887596,0.0002427376],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9302291,0.05380444,0.001200212,0.0004161416,0.0006178943,0.0006492983,0.008370999,0.0001639078,0.004547977],"genre_scores_gemma":[0.9796887,0.009034076,0.0007923242,0.0007132094,0.0004909264,0.0003861699,0.007489183,0.00003478991,0.001370538],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008005902,"threshold_uncertainty_score":0.04233974,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007663772853429656,"score_gpt":0.2497169540560801,"score_spread":0.2420531812026504,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}