{"id":"W4385402749","doi":"10.1016/j.jdcr.2023.06.051","title":"Vitiligo responds to topical aryl hydrocarbon receptor agonist tapinarof (WBI-1001)","year":2023,"lang":"en","type":"article","venue":"JAAD Case Reports","topic":"melanin and skin pigmentation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Medicine; Vitiligo; Aryl hydrocarbon receptor; Dermatology; Tacrolimus; Oxidative stress; Agonist; Ruxolitinib; Disease; Immunology; Receptor; Internal medicine; Transplantation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003513866,0.00014994,0.000150562,0.00007975204,0.0001099862,0.00003575086,0.00005182,0.0001633499,0.00007765424],"category_scores_gemma":[0.0001890134,0.0001492362,0.00009358765,0.0002199431,0.00002992795,0.00000385666,0.0001106791,0.00007638714,0.00008515315],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003030137,"about_ca_system_score_gemma":0.00006884059,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006919241,"about_ca_topic_score_gemma":0.00004334887,"domain_scores_codex":[0.9986432,0.00004696361,0.0003426382,0.0004875169,0.0002028229,0.0002769113],"domain_scores_gemma":[0.9991487,0.00001466713,0.00009701314,0.000509774,0.0000492443,0.000180546],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000123263,0.0000449132,0.001649952,0.00002180051,0.00003145497,0.02470561,0.0001260159,0.00002363429,0.9092822,0.00004870204,0.06069643,0.003246002],"study_design_scores_gemma":[0.0002892856,0.0005227032,0.002215943,0.00002579818,0.00002186214,0.01562402,0.0002530992,0.00005316318,0.696243,0.0001357113,0.2842695,0.0003459039],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948922,0.00008754196,0.0001110777,0.0006255246,0.0007225382,0.0002316405,0.0000108136,0.00005859532,0.003260103],"genre_scores_gemma":[0.9913372,0.00004835558,0.0002862991,0.0004116965,0.0005156292,0.00006762535,0.0004024799,0.00002623154,0.006904487],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2235731,"threshold_uncertainty_score":0.6085674,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01369228180737719,"score_gpt":0.2884964903916787,"score_spread":0.2748042085843015,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}