{"id":"W4385406638","doi":"10.1111/nph.19162","title":"Biosynthesis of kratom opioids","year":2023,"lang":"en","type":"article","venue":"New Phytologist","topic":"Alkaloids: synthesis and pharmacology","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of New Brunswick; Brock University","funders":"Natural Sciences and Engineering Research Council of Canada; New Brunswick Innovation Foundation","keywords":"Indole alkaloid; Tryptamine; Biosynthesis; Opium Poppy; O-methyltransferase; Biology; Biochemistry; Chemistry; Methyltransferase; Enzyme; Indole test; Gene; Botany; Papaver; Methylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.000806771,0.0003042536,0.0005756106,0.0002750233,0.0002058228,0.00001232119,0.0005954441,0.0005341708,0.007471045],"category_scores_gemma":[0.0002782263,0.0002791565,0.0002354663,0.0008408976,0.0005615587,0.00009139394,0.0001726971,0.000563625,0.002665167],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000451977,"about_ca_system_score_gemma":0.0002128099,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000122209,"about_ca_topic_score_gemma":0.00003858798,"domain_scores_codex":[0.9976156,0.0004613124,0.0005635505,0.0004586442,0.0001950302,0.0007059117],"domain_scores_gemma":[0.9977368,0.001252793,0.0002547842,0.0003553556,0.00008507965,0.0003151911],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000546022,0.0003714682,0.05572375,0.0001236051,0.000477216,0.0001260245,0.0004773333,0.0003268201,0.3688614,0.005767873,0.4872122,0.0799863],"study_design_scores_gemma":[0.001189533,0.0001721546,0.01960128,0.00001484211,0.0001907578,0.0000195692,0.000138674,0.0007035646,0.3955844,0.002374053,0.5796517,0.0003595535],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9398396,0.001286515,0.000154958,0.00508898,0.003534849,0.0005246071,0.0001749712,0.0007060034,0.0486895],"genre_scores_gemma":[0.9909477,0.0008576251,0.0002394718,0.001475581,0.0005647443,0.00004401307,0.00003232763,0.00004042161,0.005798106],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09243947,"threshold_uncertainty_score":0.9999661,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.163288845894473,"score_gpt":0.4424779176105156,"score_spread":0.2791890717160426,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}