{"id":"W4385409308","doi":"10.1080/15592294.2023.2241010","title":"Genome-wide methylation profile of mitochondrial DNA across bovine preimplantation development","year":2023,"lang":"en","type":"article","venue":"Epigenetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Biology; Mitochondrial DNA; DNA methylation; Oocyte; Methylation; Epigenetics; Genetics; Genome; Molecular biology; Gene; Blastocyst; Embryo; Embryogenesis; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000293787,0.000170813,0.0001742103,0.00007956049,0.0001211498,0.00002189495,0.0001698088,0.0001841953,0.00002552226],"category_scores_gemma":[0.0001881098,0.0001800019,0.00007214295,0.0002754898,0.00005329377,0.000004422037,0.0001312683,0.00006178616,0.00005918246],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001985919,"about_ca_system_score_gemma":0.0001209485,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000623611,"about_ca_topic_score_gemma":0.00005203116,"domain_scores_codex":[0.9985133,0.0000764459,0.0004742339,0.000348777,0.0002671804,0.000320029],"domain_scores_gemma":[0.999153,0.00004170244,0.0002096177,0.0003290632,0.0001862086,0.00008047911],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007427428,0.00003654197,0.009450053,0.00004262459,0.00004674478,0.000001141148,0.0005201167,0.001382178,0.9809908,0.000007699497,0.000134546,0.007313311],"study_design_scores_gemma":[0.0003928851,0.0002037175,0.1419475,0.00000784242,0.00001256085,4.802004e-7,0.00007319159,0.0001296662,0.827721,0.0001126923,0.02921856,0.0001799042],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9847538,0.0006147317,0.01332985,0.00003738871,0.0003681926,0.0003736275,0.00006360497,0.00003181366,0.0004269675],"genre_scores_gemma":[0.9856956,0.0005232199,0.01021429,0.0000199431,0.0003032653,0.00005029227,0.001971834,0.00004081373,0.001180736],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1532698,"threshold_uncertainty_score":0.7340263,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01943901931925626,"score_gpt":0.2897637982033831,"score_spread":0.2703247788841269,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}