{"id":"W4385409308","doi":"10.1080/15592294.2023.2241010","title":"Genome-wide methylation profile of mitochondrial DNA across bovine preimplantation development","year":2023,"lang":"en","type":"article","venue":"Epigenetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Biology; Mitochondrial DNA; DNA methylation; Oocyte; Methylation; Epigenetics; Genetics; Genome; Molecular biology; Gene; Blastocyst; Embryo; Embryogenesis; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001797429,0.0001172313,0.0002513938,0.0004575882,0.0001567398,0.0002790616,0.0001335338,0.0002081108,0.0007860325],"category_scores_gemma":[0.0002497423,0.0001287285,0.0001314211,0.0003295081,0.00009539454,0.0001247364,0.0001613501,0.0002100971,0.0001958449],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002023028,"about_ca_system_score_gemma":0.0001053185,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002829656,"about_ca_topic_score_gemma":0.005291213,"domain_scores_codex":[0.9998634,0.00001456485,0.000007223084,0.00005669256,0.0000359344,0.00002221303],"domain_scores_gemma":[0.999861,0.00002260413,0.00004967285,0.000007824258,0.00003693404,0.00002188161],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003646394,0.00001321026,0.03603532,0.0001030741,0.00004118155,0.00007921072,0.0002801697,0.0001128916,0.9519022,0.00004550797,0.00007851166,0.01094411],"study_design_scores_gemma":[0.000006504647,0.00026282,0.9143455,0.00001885099,0.00007899488,0.0003751274,0.0001599492,0.0006027084,0.08048906,0.00008178664,0.003563287,0.0000155421],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884794,0.005737659,0.003216218,0.00003146794,0.00001075189,0.00001445961,0.001395114,0.00003474909,0.001080203],"genre_scores_gemma":[0.9930314,0.001536674,0.001974823,0.000040405,0.000006674494,0.00003104442,0.001871349,0.00001731455,0.001490393],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002829656,"threshold_uncertainty_score":0.00562638,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01943901931925626,"score_gpt":0.2897637982033831,"score_spread":0.2703247788841269,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}