{"id":"W4385409401","doi":"10.1073/pnas.2303402120","title":"Genome-wide kinase-MAM interactome screening reveals the role of CK2A1 in MAM Ca <sup>2+</sup> dynamics linked to DEE66","year":2023,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Samsung Science and Technology Foundation; Ministry of Science and ICT, South Korea; National Institute of Neurological Disorders and Stroke; National Research Foundation of Korea","keywords":"Endoplasmic reticulum; Cell biology; Interactome; Phosphorylation; Biology; Mitochondrion; Cytosol; Subcellular localization; Kinase; Glutamatergic; Biochemistry; Glutamate receptor; Receptor; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001259766,0.0003264059,0.0003071214,0.0003992365,0.0002337123,0.000286484,0.0001317455,0.0002595022,0.001419691],"category_scores_gemma":[0.0001382538,0.0001052883,0.0002715916,0.0003859162,0.0001504906,0.00008198396,0.0002199987,0.0003192824,0.0002520358],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001778167,"about_ca_system_score_gemma":0.0001327092,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007122091,"about_ca_topic_score_gemma":0.001292411,"domain_scores_codex":[0.9999199,0.000009200871,0.000009903889,0.00002642821,0.00002017428,0.00001445767],"domain_scores_gemma":[0.9999074,0.00002212719,0.00003508753,0.000008145215,0.000006102004,0.00002127736],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003371669,0.00003243209,0.005474275,0.00005481097,0.00004389238,0.0005173318,0.00002305353,0.0002560165,0.9910592,0.0001337386,0.0001591971,0.001908813],"study_design_scores_gemma":[0.00007131934,0.000222024,0.4142905,0.00002147958,0.0002750277,0.00619507,0.000145325,0.01041684,0.5609779,0.0003908318,0.006960487,0.00003318942],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960438,0.0003714438,0.001408715,0.00008918197,0.000008374271,0.00000997488,0.001566999,0.00004715079,0.0004543752],"genre_scores_gemma":[0.9946929,0.0002792136,0.001730702,0.00005858269,0.000003532186,0.00001497894,0.002529335,0.0000127741,0.0006780288],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001419691,"threshold_uncertainty_score":0.004749358,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02368123559270846,"score_gpt":0.2892525670408562,"score_spread":0.2655713314481478,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}