{"id":"W4385410581","doi":"10.1164/rccm.202212-2257oc","title":"A Polygenic Risk Score for Idiopathic Pulmonary Fibrosis and Interstitial Lung Abnormalities","year":2023,"lang":"en","type":"article","venue":"American Journal of Respiratory and Critical Care Medicine","topic":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Cancer Institute; NIHR Leicester Biomedical Research Centre; National Institute of Diabetes and Digestive and Kidney Diseases; Biotechnology and Biological Sciences Research Council; Genentech; National Institutes of Health; National Center for Advancing Translational Sciences; Wellcome Trust; COPD Foundation; GlaxoSmithKline; AstraZeneca; U.S. Department of Defense; Alpha-1 Foundation; Broad Institute; National Heart, Lung, and Blood Institute; Pfizer; National Institute for Health and Care Research; U.S. Department of Veterans Affairs; Sunovion","keywords":"Medicine; Idiopathic pulmonary fibrosis; Internal medicine; Odds ratio; Oncology; Receiver operating characteristic; Lung cancer; Population; Genome-wide association study; Single-nucleotide polymorphism; Genotype; Lung; Genetics; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00192103,0.0006582218,0.0003976649,0.001799853,0.0003759628,0.0007841932,0.0005691739,0.0004675154,0.002968387],"category_scores_gemma":[0.004229296,0.0001467259,0.000969359,0.001686808,0.0004501276,0.0003546109,0.0007096751,0.000520928,0.0002424207],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002443397,"about_ca_system_score_gemma":0.0003502467,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003391453,"about_ca_topic_score_gemma":0.003368266,"domain_scores_codex":[0.9985293,0.0006037433,0.0001502812,0.0003841914,0.000252987,0.00007943639],"domain_scores_gemma":[0.9970197,0.0007476719,0.001385624,0.0003266489,0.0002629696,0.0002572641],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002654546,0.00002721266,0.9931979,0.00003104803,0.0004833487,0.0000682197,0.00003096464,0.0005197658,0.0007627601,0.0001789788,0.0003107085,0.00412363],"study_design_scores_gemma":[0.00002665035,0.0001977244,0.9939823,0.00001524806,0.0002082815,0.0004903481,0.00004433834,0.003841586,0.0002531929,0.0004695047,0.0004600841,0.00001085658],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895844,0.0006114215,0.005695479,0.0002196244,0.00002636611,0.00007130699,0.002436092,0.00009236737,0.001262963],"genre_scores_gemma":[0.9960762,0.00007702997,0.002439162,0.00004276762,0.00002298082,0.00003708069,0.001071509,0.0000055872,0.0002276202],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003391453,"threshold_uncertainty_score":0.01015949,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01725096997701557,"score_gpt":0.3063250851459222,"score_spread":0.2890741151689066,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}