{"id":"W4385410581","doi":"10.1164/rccm.202212-2257oc","title":"A Polygenic Risk Score for Idiopathic Pulmonary Fibrosis and Interstitial Lung Abnormalities","year":2023,"lang":"en","type":"article","venue":"American Journal of Respiratory and Critical Care Medicine","topic":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Cancer Institute; NIHR Leicester Biomedical Research Centre; National Institute of Diabetes and Digestive and Kidney Diseases; Biotechnology and Biological Sciences Research Council; Genentech; National Institutes of Health; National Center for Advancing Translational Sciences; Wellcome Trust; COPD Foundation; GlaxoSmithKline; AstraZeneca; U.S. Department of Defense; Alpha-1 Foundation; Broad Institute; National Heart, Lung, and Blood Institute; Pfizer; National Institute for Health and Care Research; U.S. Department of Veterans Affairs; Sunovion","keywords":"Medicine; Idiopathic pulmonary fibrosis; Internal medicine; Odds ratio; Oncology; Receiver operating characteristic; Lung cancer; Population; Genome-wide association study; Single-nucleotide polymorphism; Genotype; Lung; Genetics; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006821236,0.0002399513,0.0007789893,0.0003521665,0.0002244103,0.00002514955,0.0001024174,0.00007800492,0.00002550292],"category_scores_gemma":[0.001148852,0.0001802625,0.0002186725,0.0003076047,0.001700085,0.0001754072,0.00006607817,0.0004060949,0.000001447219],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006295595,"about_ca_system_score_gemma":0.0001790311,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004888841,"about_ca_topic_score_gemma":0.000002076233,"domain_scores_codex":[0.9981264,0.000171106,0.0006385923,0.0002765751,0.0004012035,0.00038616],"domain_scores_gemma":[0.9980431,0.0004796892,0.0002133499,0.0001583545,0.0005028768,0.0006026104],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.08413406,0.000479718,0.2669299,0.01697736,0.001183044,0.008039889,0.01899383,0.000008640213,0.03092755,0.008697026,0.008587148,0.5550418],"study_design_scores_gemma":[0.01597613,0.3592823,0.2614624,0.02921416,0.01249132,0.01120603,0.2693206,0.002345081,0.001355403,0.003741474,0.03116189,0.002443093],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9638233,0.03204148,0.0006262325,0.00237157,0.0004692021,0.0002517524,0.0001276859,0.00004592924,0.0002428372],"genre_scores_gemma":[0.995949,0.0008912198,0.0001256598,0.001192001,0.001758463,0.00001711353,0.00001004667,0.00003301531,0.00002344648],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5525987,"threshold_uncertainty_score":0.7350892,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01725096997701557,"score_gpt":0.3063250851459222,"score_spread":0.2890741151689066,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}