{"id":"W4385411631","doi":"10.1055/a-2145-5470","title":"Efficient Syntheses of (S)- and (R)-β-Proline","year":2023,"lang":"en","type":"article","venue":"Synthesis","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Proline; Decarboxylation; Nitrile; Hydrolysis; Enantiomer; Enantiomeric excess; Organic chemistry; Combinatorial chemistry; Enantioselective synthesis; Amino acid; Catalysis; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002214217,0.00009335568,0.0001729882,0.00005806308,0.00003688905,0.000006774671,0.00009802291,0.00006945604,0.00005379528],"category_scores_gemma":[0.0009944135,0.00007699831,0.0001009949,0.0001710377,0.00008969436,5.018377e-7,0.00009828415,0.00002354617,0.00001794757],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000002881287,"about_ca_system_score_gemma":0.00001073744,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001459537,"about_ca_topic_score_gemma":0.000003282597,"domain_scores_codex":[0.9993194,0.00003349352,0.0001590985,0.000227681,0.0001061764,0.0001541654],"domain_scores_gemma":[0.9994839,0.0001572903,0.00005154694,0.0002214061,0.00003042191,0.00005547352],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002332179,0.00003903825,0.00154097,0.00003520518,0.00007895726,0.000001350313,0.00001328191,0.0001455054,0.9655704,0.00005914858,0.000476677,0.03201618],"study_design_scores_gemma":[0.00004417602,0.00001915377,0.001827546,0.0000342389,0.00005368761,0.000002244908,0.00007218617,0.00167578,0.9928777,0.00004194116,0.003235535,0.000115805],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978002,0.000336854,0.00007133919,0.0002800301,0.00001369259,0.00004308708,0.00003047645,0.00001830376,0.001406058],"genre_scores_gemma":[0.9992654,0.0002146762,0.0002169276,0.00002189246,0.00006045523,0.00001713625,0.000006489304,0.00001325366,0.0001837969],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03190038,"threshold_uncertainty_score":0.31399,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01210670274076477,"score_gpt":0.2435695968292047,"score_spread":0.2314628940884399,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}