{"id":"W4385411631","doi":"10.1055/a-2145-5470","title":"Efficient Syntheses of (S)- and (R)-β-Proline","year":2023,"lang":"en","type":"article","venue":"Synthesis","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Proline; Decarboxylation; Nitrile; Hydrolysis; Enantiomer; Enantiomeric excess; Organic chemistry; Combinatorial chemistry; Enantioselective synthesis; Amino acid; Catalysis; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004156691,0.0007681377,0.0004351476,0.0003933569,0.0003434052,0.0003720825,0.0006517998,0.0004745692,0.002698374],"category_scores_gemma":[0.0003917853,0.000294085,0.0004178388,0.0004137052,0.0002386031,0.0005015869,0.0004907142,0.0007219972,0.001753562],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003174313,"about_ca_system_score_gemma":0.0005692146,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004610865,"about_ca_topic_score_gemma":0.0008853821,"domain_scores_codex":[0.9996634,0.00005551794,0.00003694703,0.0000691822,0.00008105338,0.00009402275],"domain_scores_gemma":[0.9997662,0.00002284068,0.00006311828,0.0000345823,0.00004562975,0.00006763716],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002255519,0.00007926139,0.0001356579,0.0004523985,0.00003767507,0.0007365322,0.000158855,0.000791428,0.9802386,0.001632551,0.0007388263,0.01477285],"study_design_scores_gemma":[0.00005418846,0.0004665561,0.0003430801,0.00002530251,0.00002792984,0.0006941158,0.00005930774,0.000663156,0.9808157,0.0002755528,0.01654196,0.00003309203],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8401144,0.0108035,0.08793564,0.000723103,0.0007145045,0.0005227304,0.005180327,0.0006852224,0.05332056],"genre_scores_gemma":[0.9419436,0.006552807,0.03745821,0.0001923154,0.0001078535,0.0001642003,0.001361141,0.0001699537,0.01204985],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002698374,"threshold_uncertainty_score":0.009026945,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01210670274076477,"score_gpt":0.2435695968292047,"score_spread":0.2314628940884399,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}