{"id":"W4385421510","doi":"10.1101/2023.07.30.551178","title":"Mutual dependence of Osbp and PI4KII in the maturation of regulated secretory granules","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of New Brunswick; Canada Research Chairs; Hospital for Sick Children; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Hospital for Sick Children; University of Toronto","keywords":"Cell biology; Biogenesis; Biology; Endosome; Phosphatidylinositol; Exocytosis; Lipid droplet; Intracellular; Biochemistry; Signal transduction; Membrane","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001405262,0.0005087904,0.0004346187,0.0003852103,0.0002066091,0.0004131741,0.0002837218,0.0003327083,0.00641276],"category_scores_gemma":[0.0001274139,0.000234604,0.0005218521,0.0003932158,0.0001772501,0.0003587188,0.0003426537,0.0008081425,0.0009634807],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004520402,"about_ca_system_score_gemma":0.0002830852,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004977723,"about_ca_topic_score_gemma":0.0007074879,"domain_scores_codex":[0.9998553,0.00001242479,0.000007867447,0.00004552949,0.00004445394,0.00003443997],"domain_scores_gemma":[0.9999399,0.000006393779,0.00002519444,0.00000422271,0.000009842807,0.00001437177],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000650143,0.00004292258,0.001800559,0.001080714,0.00008288152,0.0003352944,0.0000486305,0.001089329,0.9773939,0.001474624,0.002766405,0.01323461],"study_design_scores_gemma":[0.0001354754,0.0004102507,0.03180297,0.00009510051,0.0001588066,0.0005299869,0.0001249198,0.009447043,0.9190723,0.001637756,0.03653581,0.00004958325],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9171674,0.02405985,0.02633041,0.002083224,0.0007812495,0.000212612,0.01541228,0.001762589,0.01219049],"genre_scores_gemma":[0.9658184,0.008705302,0.0091532,0.0002541992,0.0001110956,0.0001814588,0.006539779,0.0001027226,0.009133794],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00641276,"threshold_uncertainty_score":0.02145284,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01250025129851758,"score_gpt":0.2092858256292243,"score_spread":0.1967855743307067,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}