{"id":"W4385429648","doi":"10.7554/elife.88149.1.sa4","title":"Author Response: Risk factors affecting polygenic score performance across diverse cohorts","year":2023,"lang":"en","type":"peer-review","venue":"","topic":"Birth, Development, and Health","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Columbia College","funders":"","keywords":"Covariate; Interaction; Demography; Multilevel model; Body mass index; Context (archaeology); Statistics; Gene–environment interaction; Medicine; Biology; Internal medicine; Mathematics; Genotype; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00723787,0.0006167152,0.0009915716,0.0005634543,0.001187226,0.001533334,0.0007318931,0.00347107,0.1429073],"category_scores_gemma":[0.05369199,0.0002926839,0.000735719,0.0009471271,0.0007182478,0.001081571,0.00148503,0.002467341,0.04089059],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005870023,"about_ca_system_score_gemma":0.0013014,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00155548,"about_ca_topic_score_gemma":0.002700215,"domain_scores_codex":[0.9944338,0.0030841,0.0005047406,0.000835121,0.0007369372,0.0004053089],"domain_scores_gemma":[0.9783013,0.01381937,0.001517962,0.001685351,0.003724437,0.0009515083],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007796487,0.00002497232,0.01516969,0.0005336002,0.0001113065,0.0001553526,0.000223502,0.0001875114,0.0001986015,0.001364032,0.9605812,0.02067049],"study_design_scores_gemma":[0.001379724,0.0005420838,0.07602933,0.001964087,0.0002975775,0.001208637,0.002840132,0.001379773,0.001334166,0.01072879,0.9020947,0.0002010651],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"other","genre_scores_codex":[0.03455742,0.008639783,0.008493044,0.6769823,0.1332224,0.0009020766,0.05275919,0.001640586,0.08280327],"genre_scores_gemma":[0.2614225,0.005016901,0.006491689,0.4777866,0.03438172,0.002781134,0.02034968,0.001547202,0.1902224],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.1429073,"threshold_uncertainty_score":0.4780724,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09827189800718837,"score_gpt":0.3957364711163416,"score_spread":0.2974645731091533,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}