{"id":"W4385441608","doi":"10.1093/neuonc/noad141","title":"Phase I trial of panobinostat in children with diffuse intrinsic pontine glioma: A report from the Pediatric Brain Tumor Consortium (PBTC-047)","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"National Cancer Institute; National Institutes of Health","keywords":"Medicine; Panobinostat; Neutropenia; Tolerability; Glioma; Population; Nausea; Toxicity; Internal medicine; Oncology; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001273514,0.001064045,0.001338955,0.0002641333,0.0003695789,0.0005147957,0.0007119712,0.0009158157,0.001550396],"category_scores_gemma":[0.000679585,0.0003477563,0.0008650676,0.0004251251,0.0004018172,0.0004171273,0.0003454692,0.002244556,0.0003950455],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009688774,"about_ca_system_score_gemma":0.002314934,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002932064,"about_ca_topic_score_gemma":0.008425537,"domain_scores_codex":[0.999651,0.0001648491,0.00002750117,0.00005180336,0.00004424153,0.00006070912],"domain_scores_gemma":[0.9994138,0.0001054006,0.0001031698,0.00004576452,0.00006005722,0.0002717888],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4307879,0.05020239,0.05302206,0.002520364,0.003434065,0.002230999,0.00154938,0.006539079,0.1113842,0.0007111142,0.01961644,0.318002],"study_design_scores_gemma":[0.4298082,0.4863997,0.05663176,0.000110719,0.00101745,0.001724271,0.0001317797,0.001497213,0.01016867,0.0002031012,0.01226769,0.00003943878],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989226,0.003257298,0.00065716,0.0007634328,0.00005899438,0.002265926,0.001710637,0.00008666165,0.001973855],"genre_scores_gemma":[0.9766335,0.004862722,0.004554775,0.00116893,0.0001281459,0.003357446,0.007187815,0.00005303881,0.002053633],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002932064,"threshold_uncertainty_score":0.007029712,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01781532449310919,"score_gpt":0.2993927966685151,"score_spread":0.281577472175406,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}