{"id":"W4385442007","doi":"10.1002/jor.25673","title":"Mechanical stress and inflammation have opposite effects on Wnt signaling in human chondrocytes","year":2023,"lang":"en","type":"article","venue":"Journal of Orthopaedic Research®","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Radboud Universitair Medisch Centrum; Radboud Universiteit; Medical Delta; Universiteit Leiden; Leids Universitair Medisch Centrum; Arthritis Society; Dutch Arthritis Society","keywords":"Wnt signaling pathway; Chondrocyte; Inflammation; DKK1; Cytokine; Cell biology; Tumor necrosis factor alpha; Signal transduction; Chemistry; Cartilage; SOX9; Osteoarthritis; Immunology; Cancer research; Medicine; Gene expression; Biology; Pathology; Anatomy; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001993777,0.0003791036,0.0003047501,0.000310347,0.0002009679,0.0004579869,0.00007603894,0.0002206975,0.001494524],"category_scores_gemma":[0.0001749642,0.0001842685,0.0003441177,0.0002650566,0.0002596148,0.0001637299,0.0002266743,0.0002674639,0.0003333083],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002114325,"about_ca_system_score_gemma":0.0002643396,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007904875,"about_ca_topic_score_gemma":0.001651934,"domain_scores_codex":[0.9996014,0.00005630328,0.00006524808,0.00007479695,0.000127324,0.00007496627],"domain_scores_gemma":[0.9998903,0.00001604048,0.00003794171,0.00001137909,0.00001927487,0.00002504137],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003285463,0.00002461063,0.0007634631,0.00006387367,0.000007240724,0.00005740065,0.00003988194,0.00001415047,0.9979007,0.00001488697,0.00001914462,0.0007659867],"study_design_scores_gemma":[0.00008653499,0.002108122,0.09325419,0.00003111789,0.00005990241,0.0008600651,0.0004143806,0.0003721682,0.8995953,0.0000662148,0.003131639,0.00002040842],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936553,0.004565081,0.0005181389,0.00007489023,0.00003277746,0.00002362656,0.0003368926,0.00001129697,0.0007820281],"genre_scores_gemma":[0.9933828,0.002823549,0.0008414672,0.0001009613,0.00002135899,0.0000789094,0.00087052,0.000007473312,0.001873079],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001494524,"threshold_uncertainty_score":0.004999697,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04746668241715431,"score_gpt":0.3618845529086988,"score_spread":0.3144178704915445,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}