{"id":"W4385442670","doi":"10.1007/s00262-023-03509-0","title":"Reovirus combined with a STING agonist enhances anti-tumor immunity in a mouse model of colorectal cancer","year":2023,"lang":"en","type":"article","venue":"Cancer Immunology Immunotherapy","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Japan Society for the Promotion of Science; Nagoya City University","keywords":"Oncolytic virus; Interferon; Sting; Innate immune system; Immune system; Stimulator of interferon genes; Biology; Immunity; Tumor microenvironment; Cancer research; Immunotherapy; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003659136,0.001114282,0.0006385433,0.001082597,0.0002545847,0.000515232,0.0004449454,0.0009543825,0.001695336],"category_scores_gemma":[0.0001907182,0.0003733505,0.0007017296,0.0003260824,0.0005491742,0.0005296352,0.0001778112,0.002723968,0.0005136937],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005203474,"about_ca_system_score_gemma":0.0004229138,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008382781,"about_ca_topic_score_gemma":0.001482047,"domain_scores_codex":[0.9995566,0.00008408893,0.00003162692,0.00007298099,0.00008810159,0.0001666971],"domain_scores_gemma":[0.9996088,0.00006575655,0.00009679017,0.00005392489,0.00001965737,0.0001551566],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001880048,0.0008714424,0.0001328794,0.00006757482,0.00001485684,0.0001122826,0.00002303871,0.000220566,0.9946612,0.0001842659,0.0001473802,0.001684539],"study_design_scores_gemma":[0.0003472236,0.007760942,0.00201866,0.00002521639,0.00007695785,0.0002886369,0.00005840491,0.002054043,0.9852969,0.0001147838,0.001941743,0.00001659447],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938126,0.001396325,0.001607885,0.0003513542,0.0002632566,0.0001051955,0.0005189996,0.0002545487,0.001689839],"genre_scores_gemma":[0.991285,0.001091647,0.001714881,0.0001445723,0.00007933826,0.000122762,0.0004720531,0.00004801698,0.00504159],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001695336,"threshold_uncertainty_score":0.005671442,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02208788827978729,"score_gpt":0.2857743054169383,"score_spread":0.263686417137151,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}