{"id":"W4385443568","doi":"10.1093/jnen/nlad059","title":"LATE-NC risk alleles (in <i>TMEM106B, GRN</i>, and <i>ABCC9</i> genes) among persons with African ancestry","year":2023,"lang":"en","type":"article","venue":"Journal of Neuropathology & Experimental Neurology","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; National Human Genome Research Institute; National Institute of Mental Health; National Institute on Aging; Stichting MS Research; Canadian Institutes of Health Research; Johns Hopkins University; University of California, San Diego; National Institutes of Health; National Institute of Neurological Disorders and Stroke; IXICO; H. Lundbeck A/S; Universitat de Barcelona; National Cancer Institute; Medical Research Council; Boston University; Servier; Newcastle University; National Institute on Minority Health and Health Disparities; Genentech; National Alzheimer's Coordinating Center; Pfizer; Biogen; BioClinica; National Center for Research Resources; F. Hoffmann-La Roche; Emory University; University of Pennsylvania; Wellcome Trust; Duke University; Foundation for the National Institutes of Health; University of Southern California; Eisai; Howard Hughes Medical Institute; Northern California Institute for Research and Education; Columbia University; Massachusetts General Hospital; North Bristol NHS Trust; Bristol-Myers Squibb; Alzheimer's Research Trust; U.S. Department of Defense; Hersenstichting; Eli Lilly and Company; BrightFocus Foundation; Novartis Pharmaceuticals Corporation; Alzheimer's Association; Indiana University; Meso Scale Diagnostics","keywords":"Allele; Hippocampal sclerosis; Disease; Single-nucleotide polymorphism; Biology; Genetics; Medicine; Gene; Genotype; Pathology; Neuroscience","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003794688,0.0003122375,0.0002511389,0.0005981099,0.0005495745,0.000278817,0.000270951,0.0004160231,0.001534454],"category_scores_gemma":[0.001059012,0.0002064932,0.0002805018,0.0005631303,0.0003031589,0.0002224092,0.0003415312,0.0002790912,0.0002094549],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001514879,"about_ca_system_score_gemma":0.0001283031,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005732665,"about_ca_topic_score_gemma":0.006616355,"domain_scores_codex":[0.9997047,0.0000748914,0.0000250015,0.0001165509,0.00003319051,0.00004556885],"domain_scores_gemma":[0.9996967,0.00005690333,0.0001314647,0.00004376265,0.00002515753,0.00004599259],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004145521,0.00006164004,0.9953519,0.000008674871,0.00003840267,0.0002229285,0.0002150169,0.00002894714,0.002115035,0.00002973126,0.00007471138,0.00143842],"study_design_scores_gemma":[0.00001509796,0.0001774171,0.9986452,0.000004178279,0.00003306616,0.0004973263,0.0001579954,0.0001125197,0.0001870883,0.00002437597,0.0001432623,0.000002559249],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996796,0.00003345988,0.00007798895,0.000005799253,9.195435e-7,0.000007703313,0.0001051422,0.000001604644,0.00008772907],"genre_scores_gemma":[0.9994876,0.00003020833,0.0001375423,0.00001845508,0.000004656893,0.00001289105,0.0001871125,0.000001717576,0.0001197682],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005732665,"threshold_uncertainty_score":0.01139855,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02481753785167514,"score_gpt":0.3011190870545265,"score_spread":0.2763015492028514,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}