{"id":"W4385445120","doi":"10.15698/mic2023.08.801","title":"Caspase 3 exhibits a yeast metacaspase proteostasis function that protects mitochondria from toxic TDP43 aggregates","year":2023,"lang":"en","type":"article","venue":"Microbial Cell","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Ottawa Hospital","funders":"Canadian Institutes of Health Research","keywords":"Proteostasis; Cell biology; Protein aggregation; Mitochondrion; Caspase; Biology; Protease; Programmed cell death; Biochemistry; Chemistry; Apoptosis; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001598342,0.000468806,0.0002987825,0.0002332842,0.0002001369,0.0003701065,0.0002094724,0.0003653644,0.0008126515],"category_scores_gemma":[0.0001828229,0.0001181274,0.0005003089,0.0002371491,0.0003242673,0.0002016142,0.0002286782,0.0005641368,0.0004893037],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004677222,"about_ca_system_score_gemma":0.0002670214,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007107073,"about_ca_topic_score_gemma":0.0007053602,"domain_scores_codex":[0.9998473,0.00002002971,0.00001888942,0.00003762443,0.00004783112,0.00002842512],"domain_scores_gemma":[0.9998341,0.00001864279,0.00005553647,0.00002826321,0.00002586563,0.00003761554],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006460796,0.00001302114,0.0002881377,0.00001847618,0.000005864039,0.00007440515,0.000006439281,0.00004544606,0.9985638,0.00009541782,0.00002039197,0.0008039693],"study_design_scores_gemma":[0.00002047709,0.000229374,0.004604388,0.000004278581,0.00001501616,0.001868668,0.00001597045,0.0008885831,0.9903337,0.0001139129,0.001898702,0.000006895952],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881902,0.001686294,0.008304116,0.0001562884,0.00003139052,0.00002969275,0.0004335496,0.000181556,0.0009869839],"genre_scores_gemma":[0.9940387,0.0003892524,0.003841713,0.00004201388,0.000004275622,0.00001341882,0.0005280157,0.00001832704,0.001124338],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008126515,"threshold_uncertainty_score":0.003393531,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03830233135621729,"score_gpt":0.2612747846264974,"score_spread":0.2229724532702801,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}