{"id":"W4385445120","doi":"10.15698/mic2023.08.801","title":"Caspase 3 exhibits a yeast metacaspase proteostasis function that protects mitochondria from toxic TDP43 aggregates","year":2023,"lang":"en","type":"article","venue":"Microbial Cell","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Ottawa Hospital","funders":"Canadian Institutes of Health Research","keywords":"Proteostasis; Cell biology; Protein aggregation; Mitochondrion; Caspase; Biology; Protease; Programmed cell death; Biochemistry; Chemistry; Apoptosis; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0002531579,0.0003681569,0.0004895891,0.0002935597,0.0002134644,0.0001211576,0.0002163045,0.0002793044,0.00172535],"category_scores_gemma":[0.0001237722,0.0003064045,0.0002458809,0.0008714387,0.0001163309,0.0001967454,0.0002399412,0.0005824608,0.00464153],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002108468,"about_ca_system_score_gemma":0.0001895795,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00131996,"about_ca_topic_score_gemma":0.0001559256,"domain_scores_codex":[0.9972912,0.0001840362,0.0003541791,0.0007751232,0.0005814474,0.0008140333],"domain_scores_gemma":[0.9986072,0.00006300316,0.000140952,0.0006336132,0.0001531736,0.0004021197],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009053968,0.0001905883,0.000305807,0.000173666,0.00009363064,0.0004018423,0.0002774227,0.00001054145,0.9770343,0.000001639415,0.01707668,0.003528481],"study_design_scores_gemma":[0.003663685,0.0005665982,0.01358478,0.0003341929,0.0001690613,0.00003729755,0.0001068397,0.0001869349,0.9621232,0.00008925523,0.01873413,0.0004040402],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932936,0.0004980963,0.0001052132,0.00173919,0.0003950484,0.002872564,0.0002001775,0.0004083822,0.000487697],"genre_scores_gemma":[0.9875523,0.0001152806,0.00081593,0.0003609834,0.0006597852,0.0003361593,0.000437146,0.0001087724,0.009613645],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01491112,"threshold_uncertainty_score":0.9999388,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03830233135621729,"score_gpt":0.2612747846264974,"score_spread":0.2229724532702801,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}