{"id":"W4385448393","doi":"10.1101/2023.07.31.551319","title":"Structure of Orthoreovirus RNA Chaperone σNS, a Component of Viral Replication Factories","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Viral gastroenteritis research and epidemiology","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Institute of General Medical Sciences; U.S. Public Health Service; Office of Science; National Institutes of Health; Heinz Endowments; U.S. Department of Energy","keywords":"RNA; Capsid; Antiparallel (mathematics); Chaperone (clinical); Viral replication; Viral protein; Mutant; Dimer; Biology; Protein subunit; Chemistry; Crystallography; Cell biology; Biophysics; Biochemistry; Virus; Virology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009338313,0.0003938753,0.0003321546,0.0002165523,0.0004180643,0.0003711072,0.0004671675,0.0004357516,0.0009223225],"category_scores_gemma":[0.0003204357,0.0002077204,0.0002505993,0.0002709546,0.0001822326,0.0003065144,0.0001867738,0.0006636613,0.000394592],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009646487,"about_ca_system_score_gemma":0.0004234092,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004921133,"about_ca_topic_score_gemma":0.003931127,"domain_scores_codex":[0.9999349,0.000006284712,0.00000387932,0.00001817383,0.00002707945,0.000009612679],"domain_scores_gemma":[0.9998957,0.00001443772,0.00002806375,0.000008388957,0.00002614635,0.00002729915],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000794838,0.000130323,0.003962026,0.0002663704,0.00006070105,0.0007701282,0.0002273479,0.006978021,0.9729463,0.001635895,0.001801586,0.01042649],"study_design_scores_gemma":[0.0003034664,0.001336246,0.1139667,0.0001745548,0.0002236684,0.002492647,0.0006873604,0.1446275,0.664067,0.004141726,0.067767,0.0002121673],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9861693,0.003142365,0.006133401,0.000328282,0.00006955096,0.00003283848,0.001201354,0.0002361297,0.002686745],"genre_scores_gemma":[0.9834261,0.001737896,0.004933779,0.0001041693,0.00002861318,0.00002552272,0.005914175,0.00006304642,0.003766734],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004921133,"threshold_uncertainty_score":0.009784997,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.035431248152632,"score_gpt":0.2908857662076381,"score_spread":0.2554545180550061,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}