{"id":"W4385450961","doi":"10.1126/scisignal.ade8744","title":"Multiple cancers escape from multiple MAPK pathway inhibitors and use DNA replication stress signaling to tolerate aberrant cell cycles","year":2023,"lang":"en","type":"article","venue":"Science Signaling","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Anschutz Medical Campus, University of Colorado; National Cancer Institute; National Institutes of Health; National Institute of Standards and Technology; Université Laval; Damon Runyon Cancer Research Foundation","keywords":"MAPK/ERK pathway; Biology; Cancer research; Cell growth; DNA damage; DNA replication; KRAS; DNA repair; Kinase; Cancer cell; Cancer; Cell biology; Mutation; DNA; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005842585,0.0002062082,0.0001686511,0.0001502656,0.0004155153,0.0001989604,0.0003240462,0.000103006,0.000008671851],"category_scores_gemma":[0.0003417028,0.0001997005,0.0000554926,0.0005217554,0.0001591835,0.00003861247,0.0002437371,0.00009345492,0.00002002339],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004566088,"about_ca_system_score_gemma":0.0002086693,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007286795,"about_ca_topic_score_gemma":0.0002414649,"domain_scores_codex":[0.997828,0.00005031904,0.0002931338,0.001005843,0.0003226386,0.0005000717],"domain_scores_gemma":[0.9988573,0.00008213049,0.0001182923,0.0005392471,0.0001336329,0.0002693687],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003323282,0.000014283,0.01060758,0.00001310262,0.00000616686,0.000006768076,0.0005529024,0.005218925,0.9816762,0.000004114944,0.0001177211,0.001749013],"study_design_scores_gemma":[0.0003447502,0.00009213092,0.003556842,0.00006520036,0.00000748554,0.000001366917,0.0007656766,0.006210445,0.9874141,0.00003150301,0.001229226,0.0002812745],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978034,0.0001388778,0.001018377,0.00006983038,0.0003524085,0.0003204333,0.0001715456,0.00006411024,0.00006097332],"genre_scores_gemma":[0.9973748,0.00003053666,0.001820996,0.0001560945,0.0002556306,0.00004775832,0.0001657846,0.00002601178,0.0001223356],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007050736,"threshold_uncertainty_score":0.8143548,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.021194317219239,"score_gpt":0.2445866611679958,"score_spread":0.2233923439487568,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}