{"id":"W4385453930","doi":"10.1021/acsomega.3c02810","title":"Trimeric Tobramycin/Nebramine Synergizes β-Lactam Antibiotics against <i>Pseudomonas aeruginosa</i>","year":2023,"lang":"en","type":"article","venue":"ACS Omega","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Aztreonam; Tobramycin; Bacterial outer membrane; Pseudomonas aeruginosa; Microbiology; Antibiotics; Imipenem; Ceftazidime; Efflux; Lactam; Bacteria; Biology; Chemistry; Antibiotic resistance; Escherichia coli; Biochemistry; Gentamicin; Stereochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008886355,0.0002627609,0.000184969,0.0001149458,0.0000623608,0.0001632901,0.0002502476,0.0002906878,0.001295882],"category_scores_gemma":[0.00007117215,0.00007931279,0.0002048826,0.0000844086,0.0001007884,0.0001617545,0.0001356678,0.0003884244,0.0003522215],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001762,"about_ca_system_score_gemma":0.0001032314,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004714895,"about_ca_topic_score_gemma":0.0007326422,"domain_scores_codex":[0.9998983,0.0000183721,0.0000101497,0.00002177335,0.00002671673,0.000024639],"domain_scores_gemma":[0.9999492,0.000005630694,0.00001582864,0.000006004221,0.000006818329,0.00001648309],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008542414,0.00002327691,0.00004546171,0.00002001587,0.000003728843,0.00001481083,0.000004281043,0.00003342974,0.9991211,0.00001504054,0.00004800271,0.0005854662],"study_design_scores_gemma":[0.00001048784,0.0004693416,0.001111912,0.000003003935,0.00001008612,0.0001138053,0.00001067226,0.0004665021,0.9964587,0.00000629798,0.001335942,0.000003281639],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936208,0.001274446,0.002120306,0.0001203036,0.00003042006,0.00003910761,0.0002233004,0.0001579181,0.002413281],"genre_scores_gemma":[0.994964,0.0004996057,0.002354149,0.00007841696,0.000006731655,0.00002449047,0.0003657319,0.00001750614,0.001689394],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001295882,"threshold_uncertainty_score":0.004335225,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01040828262494649,"score_gpt":0.2470648552520289,"score_spread":0.2366565726270824,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}