{"id":"W4385453930","doi":"10.1021/acsomega.3c02810","title":"Trimeric Tobramycin/Nebramine Synergizes β-Lactam Antibiotics against <i>Pseudomonas aeruginosa</i>","year":2023,"lang":"en","type":"article","venue":"ACS Omega","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Aztreonam; Tobramycin; Bacterial outer membrane; Pseudomonas aeruginosa; Microbiology; Antibiotics; Imipenem; Ceftazidime; Efflux; Lactam; Bacteria; Biology; Chemistry; Antibiotic resistance; Escherichia coli; Biochemistry; Gentamicin; Stereochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002520321,0.0003443064,0.0003390369,0.0001274418,0.0001511976,0.00008481111,0.0005047632,0.0002868458,0.000008656574],"category_scores_gemma":[0.0002586285,0.0003320107,0.0001545183,0.0006247647,0.0002167521,0.00001334103,0.0002880935,0.0001592613,0.0003470486],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000251388,"about_ca_system_score_gemma":0.0001136873,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001346599,"about_ca_topic_score_gemma":0.00001162858,"domain_scores_codex":[0.9979497,0.00007616211,0.0004042323,0.0006455372,0.0002721303,0.000652262],"domain_scores_gemma":[0.9986792,0.00005360063,0.0001577801,0.0008460598,0.0001032395,0.0001600991],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009432518,0.00008270118,0.01332623,0.00005008825,0.0001010245,0.00005657988,0.00002796046,0.00005957021,0.9459254,0.0001998503,0.03743724,0.002639025],"study_design_scores_gemma":[0.001235209,0.0003217143,0.036987,0.00006351645,0.00005201378,0.00002727747,0.0002054209,0.00009003724,0.796372,0.00009941571,0.1637494,0.0007970306],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926288,0.0004961441,0.0001626724,0.000371743,0.0006771879,0.0002479164,0.0000521155,0.0001602067,0.005203212],"genre_scores_gemma":[0.9891362,0.001819567,0.0007337513,0.0006862373,0.0005221689,0.000002397857,0.0006388135,0.00008349789,0.006377399],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1495534,"threshold_uncertainty_score":0.9999132,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01040828262494649,"score_gpt":0.2470648552520289,"score_spread":0.2366565726270824,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}